Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 2637547..2638175 Replicon chromosome
Accession NZ_CP054394
Organism Natranaerofaba carboxydovora strain ANCO1

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag ACONDI_RS12455 Protein ID WP_241078874.1
Coordinates 2637547..2637897 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ACONDI_RS12460 Protein ID WP_241078875.1
Coordinates 2637903..2638175 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACONDI_RS12445 (ACONDI_02482) 2633604..2636588 - 2985 WP_241078872.1 UPF0182 family protein -
ACONDI_RS12450 (ACONDI_02483) 2636650..2637474 - 825 WP_241078873.1 M55 family metallopeptidase -
ACONDI_RS12455 (ACONDI_02484) 2637547..2637897 - 351 WP_241078874.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ACONDI_RS12460 (ACONDI_02485) 2637903..2638175 - 273 WP_241078875.1 ribbon-helix-helix protein, CopG family Antitoxin
ACONDI_RS12465 (ACONDI_02486) 2638507..2639682 - 1176 WP_241078876.1 alanine racemase -
ACONDI_RS12470 (ACONDI_02487) 2639692..2640951 - 1260 WP_241078877.1 aspartate kinase -
ACONDI_RS12475 (ACONDI_02488) 2640939..2641862 - 924 WP_241078878.1 homoserine kinase -
ACONDI_RS12480 (ACONDI_02489) 2641855..2642931 - 1077 WP_241078879.1 threonine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12991.95 Da        Isoelectric Point: 8.4280

>T159595 WP_241078874.1 NZ_CP054394:c2637897-2637547 [Natranaerofaba carboxydovora]
VQIKRGDVYYADLSPVVGSEQGGVRPVLIVQNDIGNRYSPTVIVAAITSQIQKGKLPTHVEVNAKEYNLNRDSVVLLEQI
RTIDKQRLKEKVTSFSTSMMEKVDEALRISFGLIEF

Download         Length: 351 bp

>T159595 NZ_CP070088:c2267425-2267108 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10410.04 Da        Isoelectric Point: 8.5043

>AT159595 WP_241078875.1 NZ_CP054394:c2638175-2637903 [Natranaerofaba carboxydovora]
MPKTKRVMISVPNNLLQEVDGIVSSEKRNRSELIREAMRLYIRERKKDEIRQMMQKGYKEMGKINLDLANEAIEAENEAS
RLAEEMVSGA

Download         Length: 273 bp

>AT159595 NZ_CP070088:c2267115-2266828 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References