Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxT-higA/Gp49-HTH_37
Location 2479629..2480245 Replicon chromosome
Accession NZ_CP054394
Organism Natranaerofaba carboxydovora strain ANCO1

Toxin (Protein)


Gene name toxT Uniprot ID -
Locus tag ACONDI_RS11765 Protein ID WP_241078741.1
Coordinates 2479629..2479976 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ACONDI_RS11770 Protein ID WP_241078742.1
Coordinates 2479976..2480245 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACONDI_RS11730 2475588..2475854 - 267 WP_241080983.1 hypothetical protein -
ACONDI_RS11735 2475815..2476261 - 447 WP_241078735.1 copper amine oxidase N-terminal domain-containing protein -
ACONDI_RS11740 2476230..2476610 - 381 WP_241078736.1 hypothetical protein -
ACONDI_RS11745 (ACONDI_02343) 2476645..2476965 - 321 WP_241078737.1 hypothetical protein -
ACONDI_RS11750 (ACONDI_02344) 2476935..2477786 - 852 WP_241078738.1 hypothetical protein -
ACONDI_RS11755 (ACONDI_02345) 2478500..2478784 - 285 WP_241078739.1 hypothetical protein -
ACONDI_RS11760 (ACONDI_02346) 2478800..2479399 - 600 WP_241078740.1 hypothetical protein -
ACONDI_RS11765 (ACONDI_02347) 2479629..2479976 + 348 WP_241078741.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ACONDI_RS11770 (ACONDI_02348) 2479976..2480245 + 270 WP_241078742.1 helix-turn-helix transcriptional regulator Antitoxin
ACONDI_RS11775 (ACONDI_02349) 2480524..2481225 - 702 WP_241078743.1 copper amine oxidase N-terminal domain-containing protein -
ACONDI_RS11780 (ACONDI_02350) 2481501..2483699 - 2199 WP_241078744.1 stalk domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(17-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-85)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13744.99 Da        Isoelectric Point: 9.2152

>T159594 WP_241078741.1 NZ_CP054394:2479629-2479976 [Natranaerofaba carboxydovora]
MYEIIYYESFSENPVIDFISNQYPKEQAKILREIDLLQTFGISLGMPHLRKIKNTELWELRIIHGNNIFRILFKDLDKST
YLLLHGFQKKQDKTPKKEIDIALKRLKEYLEGGDR

Download         Length: 348 bp

>T159594 NZ_CP070088:c1605407-1605231 [Klebsiella pneumoniae]
GTGAAGCAAAGCGAGTTGAGGCGTTGGCTTGCAGCTCAAGGGGCAGAATTTAAAGATGGTACTAACCACTTGAAAATCTA
TCTCAACGGCAAGCAAACGGTAATGCCGAGACATCCGGGGAAGGAAATACCGGAACCGCTGAGGAAGGCAATTCTTAAGC
AACTCGGCATCAAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10573.18 Da        Isoelectric Point: 5.3071

>AT159594 WP_241078742.1 NZ_CP054394:2479976-2480245 [Natranaerofaba carboxydovora]
MKHEEAKKKLLENPEVKREYDELEYLYEIKEQIIKIRNEKGLSQKELAEILGTKQSAISRLENDMYNPTVEFLNKIAKAC
DKELEINFK

Download         Length: 270 bp

>AT159594 NZ_CP070088:c1605183-1604776 [Klebsiella pneumoniae]
ATGCGATACCCGGTAATTTTTGAGCATGACGAAACCGGCTGGGCGGTATTCTTTCCGGATATCCCAGAGGCAATGACGGG
AGGAGAGACCAGGGAGGAAGCGTTAGAAATGGCGCAAGATGCCCTGGTGACGGCGTTTGATTTTTACTTTGACGACCGCC
GGGAGATTCCCGCTCCATCAGCAGAAGGTGATGCGTTTGTTGAGGTTCCGGCCAGCGTGGCAGCTAAAGTATTGCTGTTA
AACCGTCTGGTCAGCACCAACACCAGCAATGCTGATCTCGCCCGCATGATTAACACGCGCCCACAGGAAGTGCAGCGCAT
CGTGTCTCTTGGTCACAGCACCAAAATCGATACGATCCAAAAAGCGCTATCAGCGTTGGGGCAAAAGATGGAAATTGTCG
TCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References