Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4371288..4371900 Replicon chromosome
Accession NZ_CP054388
Organism Escherichia coli strain 1517k

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag E2126_RS20680 Protein ID WP_000833473.1
Coordinates 4371288..4371473 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1M2IVK0
Locus tag E2126_RS20685 Protein ID WP_000499742.1
Coordinates 4371490..4371900 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E2126_RS20665 4366754..4368049 + 1296 WP_000985745.1 Fic family protein -
E2126_RS20670 4368157..4369695 + 1539 WP_000183978.1 aldehyde dehydrogenase AldB -
E2126_RS20675 4369736..4370815 - 1080 WP_000061475.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
E2126_RS20680 4371288..4371473 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
E2126_RS20685 4371490..4371900 + 411 WP_000499742.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E2126_RS20690 4372012..4373991 - 1980 WP_001026863.1 glycoside hydrolase family 127 protein -
E2126_RS20695 4374002..4375402 - 1401 WP_000204814.1 MFS transporter -
E2126_RS20700 4375628..4376443 + 816 WP_000891820.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T159589 WP_000833473.1 NZ_CP054388:4371288-4371473 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

>T159589 NZ_CP070087:3799024-3799126 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15242.13 Da        Isoelectric Point: 4.4482

>AT159589 WP_000499742.1 NZ_CP054388:4371490-4371900 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMDEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp

>AT159589 NZ_CP070087:c3799133-3798988 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A1M2IVK0

References