Detailed information of TA system TA159585

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 3525251..3525846
• Replicon: chromosome
• Accession: NZ_CP054388
• Organism: Escherichia coli strain 1517k

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: V0SXT4
• Locus tag: E2126_RS16710
• Protein ID: WP_000239581.1
• Coordinates: 3525251..3525601 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: L4JJX7
• Locus tag: E2126_RS16715
• Protein ID: WP_001223213.1
• Coordinates: 3525595..3525846 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E2126_RS16690	3520705..3521727	-	1023	WP_001361374.1	ABC transporter permease	-
E2126_RS16695	3521741..3523243	-	1503	WP_001095661.1	sugar ABC transporter ATP-binding protein	-
E2126_RS16700	3523376..3524332	-	957	WP_000265933.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
E2126_RS16705	3524642..3525172	+	531	WP_000055072.1	inorganic diphosphatase	-
E2126_RS16710	3525251..3525601	-	351	WP_000239581.1	endoribonuclease toxin ChpB	Toxin
E2126_RS16715	3525595..3525846	-	252	WP_001223213.1	type II toxin-antitoxin system antitoxin ChpS	Antitoxin
E2126_RS16720	3526058..3526399	-	342	WP_001219160.1	gamma-glutamylcyclotransferase	-
E2126_RS16725	3526402..3530181	-	3780	WP_128452376.1	autotransporter assembly complex protein TamB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12453.41 Da
• Isoelectric Point: 6.2206

>T159585 WP_000239581.1 NZ_CP054388:c3525601-3525251 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Nucleotide

• Length: 351 bp

>T159585 NZ_CP070087:2134423-2134791 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9331.64 Da
• Isoelectric Point: 4.6509

>AT159585 WP_001223213.1 NZ_CP054388:c3525846-3525595 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT159585 NZ_CP070087:2134205-2134426 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: V0SXT4

Antitoxin

• AlphaFold DB: L4JJX7