Detailed information of TA system TA159579

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 2455565..2456270
• Replicon: chromosome
• Accession: NZ_CP054388
• Organism: Escherichia coli strain 1517k

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1M2J6W7
• Locus tag: E2126_RS11525
• Protein ID: WP_000539524.1
• Coordinates: 2455565..2455951 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: E2126_RS11530
• Protein ID: WP_001280945.1
• Coordinates: 2455941..2456270 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E2126_RS11505	2451569..2452195	+	627	WP_001295292.1	glutathione S-transferase GstB	-
E2126_RS11510	2452192..2453307	-	1116	WP_000555056.1	aldose sugar dehydrogenase YliI	-
E2126_RS11515	2453418..2453801	-	384	WP_000497137.1	biofilm formation regulator BssR	-
E2126_RS11520	2454014..2455339	+	1326	WP_000049367.1	30S ribosomal protein S12 methylthiotransferase RimO	-
E2126_RS11525	2455565..2455951	+	387	WP_000539524.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E2126_RS11530	2455941..2456270	+	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
E2126_RS11535	2456340..2457668	-	1329	WP_000086870.1	GGDEF domain-containing protein	-
E2126_RS11540	2457676..2460024	-	2349	WP_000950331.1	EAL domain-containing protein	-
E2126_RS11545	2460201..2461112	-	912	WP_001236044.1	glutathione ABC transporter permease GsiD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14321.46 Da
• Isoelectric Point: 9.9521

>T159579 WP_000539524.1 NZ_CP054388:2455565-2455951 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSRSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T159579 NZ_CP070085:1798-2064 [Klebsiella pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT159579 WP_001280945.1 NZ_CP054388:2455941-2456270 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT159579 NZ_CP070085:1590-1814 [Klebsiella pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Structures

Toxin

• AlphaFold DB: A0A1M2J6W7