Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/- |
Location | 4417716..4418347 | Replicon | chromosome |
Accession | NZ_CP054371 | ||
Organism | Escherichia coli strain SCU-316 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | U9Y2A7 |
Locus tag | HPE41_RS20925 | Protein ID | WP_001259385.1 |
Coordinates | 4418072..4418347 (-) | Length | 92 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | U9Y7E1 |
Locus tag | HPE41_RS20920 | Protein ID | WP_000593555.1 |
Coordinates | 4417716..4418075 (-) | Length | 120 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HPE41_RS20890 | 4412828..4413301 | + | 474 | WP_001161550.1 | PTS sugar transporter subunit IIA | - |
HPE41_RS20895 | 4413298..4413579 | + | 282 | WP_000084022.1 | PTS sugar transporter subunit IIB | - |
HPE41_RS20900 | 4413656..4415014 | + | 1359 | WP_001302220.1 | PTS galactitol transporter subunit IIC | - |
HPE41_RS20905 | 4415007..4416515 | + | 1509 | WP_001298718.1 | carbohydrate kinase | - |
HPE41_RS20910 | 4416505..4416774 | + | 270 | WP_000933060.1 | HPr family phosphocarrier protein | - |
HPE41_RS20915 | 4416806..4417666 | + | 861 | WP_001131795.1 | class II aldolase | - |
HPE41_RS20920 | 4417716..4418075 | - | 360 | WP_000593555.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
HPE41_RS20925 | 4418072..4418347 | - | 276 | WP_001259385.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
HPE41_RS20930 | 4418420..4419544 | - | 1125 | WP_001314210.1 | ABC transporter permease | - |
HPE41_RS20935 | 4419544..4422279 | - | 2736 | WP_000149185.1 | ribosome-associated ATPase/putative transporter RbbA | - |
HPE41_RS20940 | 4422276..4423343 | - | 1068 | WP_000361491.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10199.94 Da Isoelectric Point: 10.7076
>T159563 WP_001259385.1 NZ_CP054371:c4418347-4418072 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP
Download Length: 276 bp
>T159563 NZ_CP070077:2362195-2362302 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 120 a.a. Molecular weight: 13402.27 Da Isoelectric Point: 5.1987
>AT159563 WP_000593555.1 NZ_CP054371:c4418075-4417716 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL
Download Length: 360 bp
>AT159563 NZ_CP070077:c2362146-2362083 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A4P7TTW8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LKZ6 |