159563

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4417716..4418347 Replicon chromosome
Accession NZ_CP054371
Organism Escherichia coli strain SCU-316

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag HPE41_RS20925 Protein ID WP_001259385.1
Coordinates 4418072..4418347 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag HPE41_RS20920 Protein ID WP_000593555.1
Coordinates 4417716..4418075 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPE41_RS20890 4412828..4413301 + 474 WP_001161550.1 PTS sugar transporter subunit IIA -
HPE41_RS20895 4413298..4413579 + 282 WP_000084022.1 PTS sugar transporter subunit IIB -
HPE41_RS20900 4413656..4415014 + 1359 WP_001302220.1 PTS galactitol transporter subunit IIC -
HPE41_RS20905 4415007..4416515 + 1509 WP_001298718.1 carbohydrate kinase -
HPE41_RS20910 4416505..4416774 + 270 WP_000933060.1 HPr family phosphocarrier protein -
HPE41_RS20915 4416806..4417666 + 861 WP_001131795.1 class II aldolase -
HPE41_RS20920 4417716..4418075 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HPE41_RS20925 4418072..4418347 - 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
HPE41_RS20930 4418420..4419544 - 1125 WP_001314210.1 ABC transporter permease -
HPE41_RS20935 4419544..4422279 - 2736 WP_000149185.1 ribosome-associated ATPase/putative transporter RbbA -
HPE41_RS20940 4422276..4423343 - 1068 WP_000361491.1 HlyD family efflux transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T159563 WP_001259385.1 NZ_CP054371:c4418347-4418072 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T159563 NZ_CP070077:2362195-2362302 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT159563 WP_000593555.1 NZ_CP054371:c4418075-4417716 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT159563 NZ_CP070077:c2362146-2362083 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References