Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1127483..1128101 Replicon chromosome
Accession NZ_CP054371
Organism Escherichia coli strain SCU-316

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HPE41_RS05295 Protein ID WP_001291435.1
Coordinates 1127483..1127701 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HPE41_RS05300 Protein ID WP_000344800.1
Coordinates 1127727..1128101 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPE41_RS05260 1122772..1123344 + 573 WP_000779831.1 YbaY family lipoprotein -
HPE41_RS05265 1123375..1123686 - 312 WP_000409914.1 MGMT family protein -
HPE41_RS05275 1124065..1124418 + 354 WP_000878146.1 DUF1428 family protein -
HPE41_RS05280 1124460..1126010 - 1551 WP_001362407.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HPE41_RS05285 1126174..1126644 - 471 WP_000136192.1 YlaC family protein -
HPE41_RS05290 1126760..1127311 - 552 WP_000102564.1 maltose O-acetyltransferase -
HPE41_RS05295 1127483..1127701 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HPE41_RS05300 1127727..1128101 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HPE41_RS05305 1128647..1131796 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
HPE41_RS05310 1131819..1133012 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T159540 WP_001291435.1 NZ_CP054371:c1127701-1127483 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T159540 NZ_CP070071:4083013-4083120 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT159540 WP_000344800.1 NZ_CP054371:c1128101-1127727 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT159540 NZ_CP070071:c4082956-4082898 [Escherichia coli]
TCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References