Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 2372758..2373465 Replicon chromosome
Accession NZ_CP054368
Organism Escherichia coli strain SCU-115

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag HPE48_RS11695 Protein ID WP_174143899.1
Coordinates 2372758..2373099 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HPE48_RS11700 Protein ID WP_059219072.1
Coordinates 2373130..2373465 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPE48_RS11675 2370296..2371093 - 798 WP_174143896.1 helix-turn-helix transcriptional regulator -
HPE48_RS11680 2371207..2371482 - 276 WP_174143897.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPE48_RS11685 2371486..2371734 - 249 WP_024187601.1 ribbon-helix-helix domain-containing protein -
HPE48_RS11690 2371810..2372643 - 834 WP_174143898.1 DUF4942 domain-containing protein -
HPE48_RS11695 2372758..2373099 - 342 WP_174143899.1 TA system toxin CbtA family protein Toxin
HPE48_RS11700 2373130..2373465 - 336 WP_059219072.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HPE48_RS11705 2373465..2373938 - 474 WP_174143900.1 DNA repair protein RadC -
HPE48_RS11710 2373968..2374786 - 819 WP_174143901.1 DUF945 domain-containing protein -
HPE48_RS11715 2375025..2375978 - 954 Protein_2296 hypothetical protein -
HPE48_RS11720 2376571..2377185 + 615 WP_174143902.1 inovirus Gp2 family protein -
HPE48_RS11725 2377303..2377521 + 219 WP_001064742.1 AlpA family phage regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 2360195..2390386 30191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(10-110)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13087.09 Da        Isoelectric Point: 10.1780

>T159517 WP_174143899.1 NZ_CP054368:c2373099-2372758 [Escherichia coli]
MKIIPATTLRATTSYLSPVVVWQTLLARLLEQHYGLNLNDTPFNNEKVIQEHIDAGITLVDAVNFLVEKYELIRIDRKGF
SWQEQTPYLRAVDILRARQATGLLRRRHNTTAR

Download         Length: 342 bp

>T159517 NZ_CP070067:c24926-24621 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTTCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGACAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGTCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12588.56 Da        Isoelectric Point: 7.1865

>AT159517 WP_059219072.1 NZ_CP054368:c2373465-2373130 [Escherichia coli]
MLQKDKVMQQEWGLPCTVTPRFTARLVQERHNLHYLADRAAITGKFSSPDLLHIDQAFPVLMKQLELKLADDELSACQQR
TVTLYAKGLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 336 bp

>AT159517 NZ_CP070067:c25146-24928 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAATTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References