Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 59575..60134 Replicon plasmid pSCU-171-1
Accession NZ_CP054364
Organism Escherichia coli strain SCU-171

Toxin (Protein)


Gene name relE Uniprot ID S1PMX5
Locus tag HPE49_RS25795 Protein ID WP_000421257.1
Coordinates 59575..59850 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HPE49_RS25800 Protein ID WP_089636645.1
Coordinates 59850..60134 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPE49_RS25765 54716..54883 + 168 WP_170987597.1 hypothetical protein -
HPE49_RS25770 54959..56158 - 1200 WP_019842812.1 lipoprotein-releasing ABC transporter permease subunit LolC -
HPE49_RS25775 56286..57182 - 897 WP_174144649.1 LysR family transcriptional regulator -
HPE49_RS25780 57312..58067 + 756 WP_089636710.1 SDR family NAD(P)-dependent oxidoreductase -
HPE49_RS25785 58105..59043 + 939 WP_019842809.1 alpha/beta hydrolase -
HPE49_RS25790 59188..59469 - 282 WP_001105058.1 hypothetical protein -
HPE49_RS25795 59575..59850 - 276 WP_000421257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPE49_RS25800 59850..60134 - 285 WP_089636645.1 ribbon-helix-helix domain-containing protein Antitoxin
HPE49_RS25805 61052..62074 - 1023 WP_000234918.1 replication initiation protein -
HPE49_RS25810 62064..62597 - 534 WP_089636643.1 replication protein -
HPE49_RS25815 62590..62664 - 75 WP_001388587.1 RepA leader peptide Tap -
HPE49_RS25820 62897..63157 - 261 WP_001595248.1 replication regulatory protein RepA -
HPE49_RS25825 63397..63987 - 591 WP_001595249.1 DUF2726 domain-containing protein -
HPE49_RS25830 64025..64234 - 210 WP_001333231.1 hemolysin expression modulator Hha -
HPE49_RS25835 64280..64741 - 462 Protein_65 thermonuclease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - iroB / iroC / iroD / iroE / iroN 1..126498 126498


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10749.45 Da        Isoelectric Point: 9.9324

>T159499 WP_000421257.1 NZ_CP054364:c59850-59575 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T159499 NZ_CP070066:310092-310199 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCACGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10597.07 Da        Isoelectric Point: 6.7244

>AT159499 WP_089636645.1 NZ_CP054364:c60134-59850 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSRHVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp

>AT159499 NZ_CP070066:c310044-309978 [Escherichia coli]
GGTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PMX5

Antitoxin

Source ID Structure

References