Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/DinJ(antitoxin)
Location 36400..36848 Replicon plasmid pSCU-171-1
Accession NZ_CP054364
Organism Escherichia coli strain SCU-171

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag HPE49_RS25640 Protein ID WP_089636607.1
Coordinates 36400..36582 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag HPE49_RS25645 Protein ID WP_089636606.1
Coordinates 36579..36848 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPE49_RS25625 31422..33599 - 2178 WP_089636611.1 siderophore salmochelin receptor IroN -
HPE49_RS25630 34464..35498 - 1035 WP_089636610.1 3-deoxy-7-phosphoheptulonate synthase -
HPE49_RS25635 35993..36301 - 309 WP_089636608.1 hypothetical protein -
HPE49_RS25640 36400..36582 - 183 WP_089636607.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPE49_RS25645 36579..36848 - 270 WP_089636606.1 hypothetical protein Antitoxin
HPE49_RS25650 37459..38733 + 1275 WP_000489607.1 HlyD family secretion protein -
HPE49_RS25655 38708..40822 + 2115 WP_122988972.1 peptidase domain-containing ABC transporter -
HPE49_RS25660 40992..41303 - 312 WP_001259758.1 colicin V -
HPE49_RS25665 41281..41517 - 237 WP_001323890.1 colicin V immunity protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - iroB / iroC / iroD / iroE / iroN 1..126498 126498


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6959.13 Da        Isoelectric Point: 4.8892

>T159498 WP_089636607.1 NZ_CP054364:c36582-36400 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGCSASLLFSLSFISVRVHDNIITV

Download         Length: 183 bp

>T159498 NZ_CP070066:309610-309717 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10211.59 Da        Isoelectric Point: 6.4618

>AT159498 WP_089636606.1 NZ_CP054364:c36848-36579 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDCNGSQLIRDFMRQTVERQHNIWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT159498 NZ_CP070066:c309553-309496 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References