Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3835122..3835546 Replicon chromosome
Accession NZ_CP054363
Organism Escherichia coli strain SCU-171

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag HPE49_RS18485 Protein ID WP_001306201.1
Coordinates 3835358..3835546 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0J2BBI0
Locus tag HPE49_RS18480 Protein ID WP_000125563.1
Coordinates 3835122..3835355 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPE49_RS18455 3830195..3830482 + 288 WP_000203741.1 ferredoxin-like protein FixX -
HPE49_RS18460 3830541..3831872 + 1332 WP_001183198.1 MFS transporter -
HPE49_RS18465 3831980..3832510 + 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
HPE49_RS18470 3832503..3834365 + 1863 WP_000377115.1 glutathione-regulated potassium-efflux system protein KefC -
HPE49_RS18475 3834557..3835036 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
HPE49_RS18480 3835122..3835355 + 234 WP_000125563.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
HPE49_RS18485 3835358..3835546 + 189 WP_001306201.1 CcdB family protein Toxin
HPE49_RS18490 3835543..3835659 + 117 WP_000148634.1 CcdB family protein -
HPE49_RS18495 3835656..3836504 - 849 WP_000257195.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
HPE49_RS18500 3836511..3836888 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
HPE49_RS18505 3836891..3837712 - 822 WP_001065361.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
HPE49_RS18510 3837709..3838698 - 990 WP_000241249.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
HPE49_RS18515 3838698..3839984 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-57)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7167.44 Da        Isoelectric Point: 11.6113

>T159493 WP_001306201.1 NZ_CP054363:3835358-3835546 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFIRIRPPERLNTILLLVDGS

Download         Length: 189 bp

>T159493 NZ_CP070063:c4058548-4058396 [Escherichia coli]
ATGCTGACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGTTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8542.58 Da        Isoelectric Point: 5.8062

>AT159493 WP_000125563.1 NZ_CP054363:3835122-3835355 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAAIRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT159493 NZ_CP070063:4058590-4058642 [Escherichia coli]
TTAGGTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0J2BBI0

References