Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3097230..3097833 Replicon chromosome
Accession NZ_CP054363
Organism Escherichia coli strain SCU-171

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag HPE49_RS14925 Protein ID WP_012906750.1
Coordinates 3097654..3097833 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A828HJ79
Locus tag HPE49_RS14920 Protein ID WP_032210866.1
Coordinates 3097230..3097628 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPE49_RS14895 3092425..3093048 + 624 WP_159107718.1 ash family protein -
HPE49_RS14900 3093045..3094967 + 1923 WP_052431184.1 replication endonuclease -
HPE49_RS14905 3095117..3095362 + 246 WP_042103142.1 hypothetical protein -
HPE49_RS14910 3095373..3096446 + 1074 WP_042103145.1 DUF968 domain-containing protein -
HPE49_RS14915 3096448..3097140 + 693 WP_042103148.1 hypothetical protein -
HPE49_RS14920 3097230..3097628 - 399 WP_032210866.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HPE49_RS14925 3097654..3097833 - 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
HPE49_RS14930 3098266..3098526 + 261 WP_032210867.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPE49_RS14935 3098586..3098960 + 375 WP_032210883.1 helix-turn-helix domain-containing protein -
HPE49_RS14940 3099248..3099679 + 432 WP_028985991.1 tellurite resistance TerB family protein -
HPE49_RS14945 3099676..3099834 + 159 WP_032210869.1 DUF3927 family protein -
HPE49_RS14950 3100817..3102784 + 1968 WP_174144486.1 SASA family carbohydrate esterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3082377..3129070 46693


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T159490 WP_012906750.1 NZ_CP054363:c3097833-3097654 [Escherichia coli]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T159490 NZ_CP070063:c3248150-3247818 [Escherichia coli]
ATGGACAGAGGGGAAATCTGGCTGGTTTCACTGGATCCGATTGCAGGTCACGAGCAAAGCGGAAAACGTCCGGTGCTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGACCCGGCTACCCGTTGTTGTTCCCGTTACCAGCGGCGGAAACTTCGCCCGTG
CAGCCGGTTTTACCGTCTCACTGGACGGTGCGGGAACAAAAACAACGGGCGTTATTCGCTGCGACCAGCCCAGAACCATT
GATATGGGAGCCCGGAGCGGTAAGCGACTGGAACGTATACCCGATGCTGTCGTGAATGAAGTGCTGGCCCGACTGGAGGC
CATTCTGAGCTGA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14264.10 Da        Isoelectric Point: 4.3752

>AT159490 WP_032210866.1 NZ_CP054363:c3097628-3097230 [Escherichia coli]
MLYPVAIDKSDSSFGVRVPDIPGCFSGGNSYQDAIESAHEAIEAHIELLVEEGEAVPKATSMDNWLADPDYSGAVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKITG

Download         Length: 399 bp

>AT159490 NZ_CP070063:c3248408-3248151 [Escherichia coli]
ATGTATACAACTCGCCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCCCCCGCCGTGCTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAGTTGTTGGCGCAGTGCGATCCGCACGCAGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A828HJ79

References