Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2042341..2043139 Replicon chromosome
Accession NZ_CP054363
Organism Escherichia coli strain SCU-171

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1M0ZYM8
Locus tag HPE49_RS09810 Protein ID WP_000854904.1
Coordinates 2042762..2043139 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A093DMQ4
Locus tag HPE49_RS09805 Protein ID WP_001280952.1
Coordinates 2042341..2042715 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPE49_RS09775 2039180..2039635 + 456 WP_000581504.1 hypothetical protein -
HPE49_RS09780 2039714..2039947 + 234 WP_001119729.1 DUF905 family protein -
HPE49_RS09785 2040047..2040865 + 819 WP_001234620.1 DUF945 domain-containing protein -
HPE49_RS09790 2040920..2041405 + 486 WP_174144461.1 antirestriction protein -
HPE49_RS09795 2041421..2041897 + 477 WP_001186726.1 RadC family protein -
HPE49_RS09800 2041957..2042178 + 222 WP_000692315.1 DUF987 domain-containing protein -
HPE49_RS09805 2042341..2042715 + 375 WP_001280952.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HPE49_RS09810 2042762..2043139 + 378 WP_000854904.1 TA system toxin CbtA family protein Toxin
HPE49_RS09815 2043136..2043624 + 489 WP_000779175.1 hypothetical protein -
HPE49_RS09820 2043636..2043833 + 198 WP_000839249.1 DUF957 domain-containing protein -
HPE49_RS09825 2044047..2045066 + 1020 WP_000875212.1 IS110 family transposase -
HPE49_RS09830 2045350..2046192 + 843 WP_001280528.1 DUF4942 domain-containing protein -
HPE49_RS09835 2046535..2047071 - 537 WP_000942807.1 GspM family type II secretion system protein YghD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - clpV/tssH / hcp/tssD / vipB/tssC / vipA/tssB / gspM / gspL / gspK / gspJ / gspI / gspH / gspG / gspF / gspE / gspD / gspC 1826756..2063016 236260
- flank IS/Tn - - 2044047..2045066 1019


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-118)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14280.26 Da        Isoelectric Point: 7.2922

>T159483 WP_000854904.1 NZ_CP054363:2042762-2043139 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T159483 NZ_CP070063:1501207-1501605 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13719.50 Da        Isoelectric Point: 6.6249

>AT159483 WP_001280952.1 NZ_CP054363:2042341-2042715 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS

Download         Length: 375 bp

>AT159483 NZ_CP070063:1500911-1501204 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M0ZYM8

Antitoxin

Source ID Structure
AlphaFold DB A0A093DMQ4

References