Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 845973..846523 Replicon chromosome
Accession NZ_CP054353
Organism Escherichia coli strain SCU-172

Toxin (Protein)


Gene name ccdB Uniprot ID S1PDG4
Locus tag HPE50_RS04010 Protein ID WP_001160966.1
Coordinates 846209..846523 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1NMQ0
Locus tag HPE50_RS04005 Protein ID WP_000125568.1
Coordinates 845973..846206 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPE50_RS03980 841046..841333 + 288 WP_001570923.1 ferredoxin-like protein FixX -
HPE50_RS03985 841392..842723 + 1332 WP_001183201.1 MFS transporter -
HPE50_RS03990 842831..843361 + 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
HPE50_RS03995 843354..845216 + 1863 WP_000377117.1 glutathione-regulated potassium-efflux system protein KefC -
HPE50_RS04000 845408..845887 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
HPE50_RS04005 845973..846206 + 234 WP_000125568.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
HPE50_RS04010 846209..846523 + 315 WP_001160966.1 CcdB family protein Toxin
HPE50_RS04015 846520..847368 - 849 WP_001570924.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
HPE50_RS04020 847375..847752 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
HPE50_RS04025 847755..848576 - 822 WP_001065381.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
HPE50_RS04030 848573..849562 - 990 WP_000241224.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
HPE50_RS04035 849562..850848 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.72 Da        Isoelectric Point: 9.0851

>T159436 WP_001160966.1 NZ_CP054353:846209-846523 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

>T159436 NZ_CP070046:c1415685-1415275 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8560.55 Da        Isoelectric Point: 5.8062

>AT159436 WP_000125568.1 NZ_CP054353:845973-846206 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENTEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT159436 NZ_CP070046:c1415932-1415666 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G815

Antitoxin

Source ID Structure
AlphaFold DB A0A829GEF2

References