159429

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4052325..4052822 Replicon chromosome
Accession NZ_CP054345
Organism Escherichia coli strain SCU-176

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag HPE52_RS19590 Protein ID WP_001173343.1
Coordinates 4052325..4052498 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag HPE52_RS19595 Protein ID WP_001312331.1
Coordinates 4052526..4052822 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPE52_RS19580 4048995..4050452 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
HPE52_RS19585 4050689..4052206 + 1518 WP_000003806.1 lysine--tRNA ligase -
HPE52_RS19590 4052325..4052498 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
HPE52_RS19595 4052526..4052822 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
HPE52_RS19600 4053051..4053323 - 273 WP_174165891.1 N-acetyltransferase -
HPE52_RS19605 4053335..4053565 - 231 WP_000373293.1 (4Fe-4S)-binding protein -
HPE52_RS19610 4053746..4055377 + 1632 WP_001216482.1 sensor histidine kinase -
HPE52_RS19615 4055374..4056093 + 720 WP_001540474.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T159429 WP_001173343.1 NZ_CP054345:c4052498-4052325 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T159429 NZ_CP070045:c4031125-4031018 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCACGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT159429 WP_001312331.1 NZ_CP054345:c4052822-4052526 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp

>AT159429 NZ_CP070045:4031173-4031239 [Escherichia coli]
GGTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References