Detailed information of TA system TA159428

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4040266..4041098
• Replicon: chromosome
• Accession: NZ_CP054345
• Organism: Escherichia coli strain SCU-176

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HPE52_RS19545
• Protein ID: WP_097330396.1
• Coordinates: 4040724..4041098 (+)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HPE52_RS19540
• Protein ID: WP_097430602.1
• Coordinates: 4040266..4040634 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPE52_RS19505	4036185..4036865	+	681	WP_073313349.1	WYL domain-containing protein	-
HPE52_RS19510	4037013..4037690	+	678	WP_174165906.1	hypothetical protein	-
HPE52_RS19515	4037696..4037929	+	234	WP_001278287.1	DUF905 family protein	-
HPE52_RS19520	4038019..4038855	+	837	WP_097330433.1	DUF932 domain-containing protein	-
HPE52_RS19525	4038937..4039416	+	480	WP_000860081.1	antirestriction protein	-
HPE52_RS19530	4039432..4039908	+	477	WP_001186773.1	RadC family protein	-
HPE52_RS19535	4039971..4040192	+	222	WP_000692323.1	DUF987 domain-containing protein	-
HPE52_RS19540	4040266..4040634	+	369	WP_097430602.1	type IV toxin-antitoxin system toxin CbtA	Antitoxin
HPE52_RS19545	4040724..4041098	+	375	WP_097330396.1	TA system toxin CbtA family protein	Toxin
HPE52_RS19550	4041095..4041586	+	492	WP_123002559.1	hypothetical protein	-
HPE52_RS19555	4041598..4041795	+	198	WP_000839256.1	DUF957 domain-containing protein	-
HPE52_RS19560	4041880..4042722	+	843	WP_001280501.1	DUF4942 domain-containing protein	-
HPE52_RS19565	4043471..4045009	+	1539	WP_001187191.1	lysine decarboxylation/transport transcriptional activator CadC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4028457..4045009	16552

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13967.83 Da
• Isoelectric Point: 6.8601

>T159428 WP_097330396.1 NZ_CP054345:4040724-4041098 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGNYPEAK

Nucleotide

• Length: 375 bp

>T159428 NZ_CP070045:c4030642-4030535 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13580.40 Da
• Isoelectric Point: 5.9505

>AT159428 WP_097430602.1 NZ_CP054345:4040266-4040634 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Nucleotide

• Length: 369 bp

>AT159428 NZ_CP070045:4030699-4030756 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT