Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 478158..478992 Replicon chromosome
Accession NZ_CP054345
Organism Escherichia coli strain SCU-176

Toxin (Protein)


Gene name yeeV Uniprot ID S1PLF5
Locus tag HPE52_RS02280 Protein ID WP_000854690.1
Coordinates 478158..478535 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1P7N8
Locus tag HPE52_RS02285 Protein ID WP_001305076.1
Coordinates 478624..478992 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPE52_RS02250 474538..474708 - 171 Protein_439 IS110 family transposase -
HPE52_RS02255 475179..476072 - 894 WP_021528665.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
HPE52_RS02260 476065..476460 - 396 WP_000208382.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
HPE52_RS02265 476529..477374 - 846 WP_001529401.1 DUF4942 domain-containing protein -
HPE52_RS02270 477459..477656 - 198 WP_000839293.1 DUF957 domain-containing protein -
HPE52_RS02275 477673..478161 - 489 WP_000761699.1 hypothetical protein -
HPE52_RS02280 478158..478535 - 378 WP_000854690.1 TA system toxin CbtA family protein Toxin
HPE52_RS02285 478624..478992 - 369 WP_001305076.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HPE52_RS02290 479042..479686 - 645 WP_000094916.1 hypothetical protein -
HPE52_RS02295 479705..479926 - 222 WP_000692329.1 DUF987 domain-containing protein -
HPE52_RS02300 479989..480465 - 477 WP_001186726.1 RadC family protein -
HPE52_RS02305 480481..480966 - 486 WP_000849565.1 antirestriction protein -
HPE52_RS02310 481021..481839 - 819 WP_160521617.1 DUF945 domain-containing protein -
HPE52_RS02315 481940..482173 - 234 WP_000902034.1 DUF905 family protein -
HPE52_RS02320 482252..482707 - 456 WP_000581502.1 hypothetical protein -
HPE52_RS02325 482783..483910 - 1128 Protein_454 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14057.04 Da        Isoelectric Point: 9.1510

>T159407 WP_000854690.1 NZ_CP054345:c478535-478158 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T159407 NZ_CP070041:3382187-3382294 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13560.39 Da        Isoelectric Point: 4.7830

>AT159407 WP_001305076.1 NZ_CP054345:c478992-478624 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT159407 NZ_CP070041:c3382138-3382075 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PLF5

Antitoxin

Source ID Structure
AlphaFold DB S1P7N8

References