Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 478158..478992 | Replicon | chromosome |
Accession | NZ_CP054345 | ||
Organism | Escherichia coli strain SCU-176 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | S1PLF5 |
Locus tag | HPE52_RS02280 | Protein ID | WP_000854690.1 |
Coordinates | 478158..478535 (-) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | S1P7N8 |
Locus tag | HPE52_RS02285 | Protein ID | WP_001305076.1 |
Coordinates | 478624..478992 (-) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HPE52_RS02250 | 474538..474708 | - | 171 | Protein_439 | IS110 family transposase | - |
HPE52_RS02255 | 475179..476072 | - | 894 | WP_021528665.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
HPE52_RS02260 | 476065..476460 | - | 396 | WP_000208382.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | - |
HPE52_RS02265 | 476529..477374 | - | 846 | WP_001529401.1 | DUF4942 domain-containing protein | - |
HPE52_RS02270 | 477459..477656 | - | 198 | WP_000839293.1 | DUF957 domain-containing protein | - |
HPE52_RS02275 | 477673..478161 | - | 489 | WP_000761699.1 | hypothetical protein | - |
HPE52_RS02280 | 478158..478535 | - | 378 | WP_000854690.1 | TA system toxin CbtA family protein | Toxin |
HPE52_RS02285 | 478624..478992 | - | 369 | WP_001305076.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
HPE52_RS02290 | 479042..479686 | - | 645 | WP_000094916.1 | hypothetical protein | - |
HPE52_RS02295 | 479705..479926 | - | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
HPE52_RS02300 | 479989..480465 | - | 477 | WP_001186726.1 | RadC family protein | - |
HPE52_RS02305 | 480481..480966 | - | 486 | WP_000849565.1 | antirestriction protein | - |
HPE52_RS02310 | 481021..481839 | - | 819 | WP_160521617.1 | DUF945 domain-containing protein | - |
HPE52_RS02315 | 481940..482173 | - | 234 | WP_000902034.1 | DUF905 family protein | - |
HPE52_RS02320 | 482252..482707 | - | 456 | WP_000581502.1 | hypothetical protein | - |
HPE52_RS02325 | 482783..483910 | - | 1128 | Protein_454 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14057.04 Da Isoelectric Point: 9.1510
>T159407 WP_000854690.1 NZ_CP054345:c478535-478158 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
Download Length: 378 bp
>T159407 NZ_CP070041:3382187-3382294 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13560.39 Da Isoelectric Point: 4.7830
>AT159407 WP_001305076.1 NZ_CP054345:c478992-478624 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
Download Length: 369 bp
>AT159407 NZ_CP070041:c3382138-3382075 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|