Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-MazE |
| Location | 3605055..3605684 | Replicon | chromosome |
| Accession | NZ_CP054306 | ||
| Organism | Synechocystis sp. PCC 7338 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | HTZ78_RS16835 | Protein ID | WP_249213932.1 |
| Coordinates | 3605055..3605393 (-) | Length | 113 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | HTZ78_RS16840 | Protein ID | WP_212717673.1 |
| Coordinates | 3605457..3605684 (-) | Length | 76 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HTZ78_RS16790 (HTZ78_16785) | 3600708..3601559 | - | 852 | WP_212717663.1 | RMD1 family protein | - |
| HTZ78_RS16795 (HTZ78_16790) | 3601673..3602314 | - | 642 | WP_194017876.1 | hypothetical protein | - |
| HTZ78_RS16800 (HTZ78_16795) | 3602578..3602913 | - | 336 | WP_212717664.1 | DUF86 domain-containing protein | - |
| HTZ78_RS16805 (HTZ78_16800) | 3602903..3603241 | - | 339 | WP_212717665.1 | nucleotidyltransferase domain-containing protein | - |
| HTZ78_RS16810 (HTZ78_16805) | 3603333..3603452 | - | 120 | WP_249214046.1 | DUF86 domain-containing protein | - |
| HTZ78_RS16815 (HTZ78_16810) | 3603490..3603657 | - | 168 | WP_223343214.1 | nucleotidyltransferase domain-containing protein | - |
| HTZ78_RS16820 (HTZ78_16815) | 3603662..3603997 | - | 336 | WP_212717667.1 | DUF86 domain-containing protein | - |
| HTZ78_RS16825 (HTZ78_16820) | 3603981..3604301 | - | 321 | WP_223341787.1 | nucleotidyltransferase family protein | - |
| HTZ78_RS16830 (HTZ78_16825) | 3604689..3604919 | - | 231 | WP_212717668.1 | hypothetical protein | - |
| HTZ78_RS16835 (HTZ78_16830) | 3605055..3605393 | - | 339 | WP_249213932.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| HTZ78_RS16840 (HTZ78_16835) | 3605457..3605684 | - | 228 | WP_212717673.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| HTZ78_RS16845 (HTZ78_16840) | 3605807..3606076 | - | 270 | WP_212717675.1 | Txe/YoeB family addiction module toxin | - |
| HTZ78_RS16850 (HTZ78_16845) | 3606057..3606329 | - | 273 | WP_212717677.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HTZ78_RS16855 (HTZ78_16850) | 3606346..3608700 | - | 2355 | WP_249213933.1 | N-6 DNA methylase | - |
| HTZ78_RS16860 (HTZ78_16855) | 3609123..3609335 | - | 213 | WP_212717679.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| HTZ78_RS16865 (HTZ78_16860) | 3609332..3609553 | - | 222 | WP_212717680.1 | type II toxin-antitoxin system HicA family toxin | - |
| HTZ78_RS16870 (HTZ78_16865) | 3609613..3609849 | - | 237 | WP_212717685.1 | DUF2283 domain-containing protein | - |
| HTZ78_RS16875 (HTZ78_16870) | 3609836..3610117 | - | 282 | WP_212717687.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 113 a.a. Molecular weight: 12321.17 Da Isoelectric Point: 5.1069
>T159403 WP_249213932.1 NZ_CP054306:c3605393-3605055 [Synechocystis sp. PCC 7338]
MAKLQALEVSEVGISSITLAELEYGVSKSQRQSKNRDALMQFLLPLEIVEFNQEAAIAYGNIRSNLESRGLVIGAMDMLI
AAHALSLGVTLVSNNVREFSRINNLSLENWAK
MAKLQALEVSEVGISSITLAELEYGVSKSQRQSKNRDALMQFLLPLEIVEFNQEAAIAYGNIRSNLESRGLVIGAMDMLI
AAHALSLGVTLVSNNVREFSRINNLSLENWAK
Download Length: 339 bp
>T159403 NZ_CP070041:c2394127-2393840 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8482.58 Da Isoelectric Point: 4.0385
>AT159403 WP_212717673.1 NZ_CP054306:c3605684-3605457 [Synechocystis sp. PCC 7338]
MNTAQISTDGTHQIIILPENFTIAGSEVYIKKIGSTIILIAKDNPWQSLIESLDQFSDDFMATREQPPLDVREEF
MNTAQISTDGTHQIIILPENFTIAGSEVYIKKIGSTIILIAKDNPWQSLIESLDQFSDDFMATREQPPLDVREEF
Download Length: 228 bp
>AT159403 NZ_CP070041:c2393853-2393551 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|