Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) brnT-shpB/BrnT_toxin-BrnA
Location 3204818..3205328 Replicon chromosome
Accession NZ_CP054306
Organism Synechocystis sp. PCC 7338

Toxin (Protein)


Gene name brnT Uniprot ID -
Locus tag HTZ78_RS14965 Protein ID WP_212717122.1
Coordinates 3205050..3205328 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag HTZ78_RS14960 Protein ID WP_249213909.1
Coordinates 3204818..3205030 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HTZ78_RS14940 (HTZ78_14935) 3200266..3201009 - 744 WP_212717117.1 3-oxoacyl-[acyl-carrier-protein] reductase -
HTZ78_RS14945 (HTZ78_14940) 3201126..3203894 - 2769 WP_212717118.1 helicase-related protein -
HTZ78_RS18280 3203903..3204103 - 201 WP_249213908.1 hypothetical protein -
HTZ78_RS14955 (HTZ78_14950) 3204352..3204696 - 345 WP_212717119.1 hypothetical protein -
HTZ78_RS14960 (HTZ78_14955) 3204818..3205030 - 213 WP_249213909.1 BrnA antitoxin family protein Antitoxin
HTZ78_RS14965 (HTZ78_14960) 3205050..3205328 - 279 WP_212717122.1 BrnT family toxin Toxin
HTZ78_RS18285 (HTZ78_14965) 3205358..3208411 - 3054 WP_249213910.1 DUF1156 domain-containing protein -
HTZ78_RS14975 (HTZ78_14970) 3208478..3208804 + 327 WP_212717124.1 hypothetical protein -
HTZ78_RS14980 (HTZ78_14975) 3208801..3209244 + 444 WP_212717126.1 type II toxin-antitoxin system YhaV family toxin -
HTZ78_RS14985 (HTZ78_14980) 3209287..3209511 + 225 WP_212717128.1 DUF433 domain-containing protein -
HTZ78_RS14990 (HTZ78_14985) 3209508..3209840 + 333 WP_212717129.1 DUF5615 family PIN-like protein -
HTZ78_RS18290 3209909..3210091 - 183 WP_249213911.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-82)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(10-64)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 11059.47 Da        Isoelectric Point: 5.6514

>T159402 WP_212717122.1 NZ_CP054306:c3205328-3205050 [Synechocystis sp. PCC 7338]
MQFEWDEAKNLENIRKHEIDFADVPTMFDSEMLIEFDNRSDYGEERWIGIGFLGPGVAVVVWTERFQNLIRIISARRANN
HEKKRFQRYISH

Download         Length: 279 bp

>T159402 NZ_CP070041:2325512-2325664 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 8118.03 Da        Isoelectric Point: 4.1074

>AT159402 WP_249213909.1 NZ_CP054306:c3205030-3204818 [Synechocystis sp. PCC 7338]
MSDEDIDYSDIPPLTNSFFERAKLVIPSTQAKNLVEIDSDLIQWFKSKGENYSHLINEALRQYIQVEESP

Download         Length: 213 bp

>AT159402 NZ_CP070041:c2325463-2325406 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References