Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 913518..914156 Replicon chromosome
Accession NZ_CP054306
Organism Synechocystis sp. PCC 7338

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HTZ78_RS04415 Protein ID WP_212719972.1
Coordinates 913755..914156 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HTZ78_RS04410 Protein ID WP_212721948.1
Coordinates 913518..913745 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HTZ78_RS04390 (HTZ78_04390) 908997..909647 + 651 WP_212719966.1 class I SAM-dependent methyltransferase -
HTZ78_RS04395 (HTZ78_04395) 909648..910853 + 1206 WP_212719968.1 glycosyltransferase family 4 protein -
HTZ78_RS04400 (HTZ78_04400) 910870..912240 + 1371 WP_212719969.1 hypothetical protein -
HTZ78_RS04405 (HTZ78_04405) 912260..913450 + 1191 WP_212719971.1 glycosyltransferase family 4 protein -
HTZ78_RS04410 (HTZ78_04410) 913518..913745 + 228 WP_212721948.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HTZ78_RS04415 (HTZ78_04415) 913755..914156 + 402 WP_212719972.1 tRNA(fMet)-specific endonuclease VapC Toxin
HTZ78_RS04420 (HTZ78_04420) 914268..915455 + 1188 WP_249213989.1 glycosyltransferase -
HTZ78_RS04425 (HTZ78_04425) 915629..916186 + 558 WP_212719974.1 DUF874 family protein -
HTZ78_RS04430 (HTZ78_04430) 916263..916808 + 546 WP_212719983.1 Uma2 family endonuclease -
HTZ78_RS04435 (HTZ78_04435) 916968..917510 + 543 WP_212721965.1 WcaF family extracellular polysaccharide biosynthesis acetyltransferase -
HTZ78_RS04440 (HTZ78_04440) 917574..918848 + 1275 WP_212719984.1 glycosyltransferase family 4 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14972.48 Da        Isoelectric Point: 9.5071

>T159401 WP_212719972.1 NZ_CP054306:913755-914156 [Synechocystis sp. PCC 7338]
MLKYMLDTNIVIYTMKNKPSQVRTLFKKHDGQMCISSVTLGELVFGAERSAMPEKNLSAIDNLIARMEVEFFDIKGATHF
GQIKAELAQRGTPIGPYDTMIAGHARSLGLILVTNNLKEFERIKGLRLENWAN

Download         Length: 402 bp

>T159401 NZ_CP070041:c2288577-2288263 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8723.88 Da        Isoelectric Point: 6.9483

>AT159401 WP_212721948.1 NZ_CP054306:913518-913745 [Synechocystis sp. PCC 7338]
IQTNVFRNNKTQAVRLPKMVELPENIKKITIVAVGNTRIITPVGESWDDWFDNCHVSSDFMNCREQPKDQSRESF

Download         Length: 228 bp

>AT159401 NZ_CP070041:c2288813-2288580 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References