Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 175726..176285 Replicon chromosome
Accession NZ_CP054306
Organism Synechocystis sp. PCC 7338

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HTZ78_RS00915 Protein ID WP_190599655.1
Coordinates 175947..176285 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HTZ78_RS00910 Protein ID WP_212718063.1
Coordinates 175726..175950 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HTZ78_RS00885 (HTZ78_00885) 170734..171936 + 1203 WP_212718055.1 class I SAM-dependent methyltransferase -
HTZ78_RS00890 (HTZ78_00890) 171976..172467 - 492 WP_212718057.1 hypothetical protein -
HTZ78_RS00895 (HTZ78_00895) 172675..173214 + 540 WP_212718058.1 TerD family protein -
HTZ78_RS00900 (HTZ78_00900) 173325..173915 + 591 WP_212718059.1 hypothetical protein -
HTZ78_RS00905 (HTZ78_00905) 174163..175566 - 1404 WP_212718060.1 glutamate decarboxylase -
HTZ78_RS00910 (HTZ78_00910) 175726..175950 + 225 WP_212718063.1 DUF433 domain-containing protein Antitoxin
HTZ78_RS00915 (HTZ78_00915) 175947..176285 + 339 WP_190599655.1 DUF5615 family PIN-like protein Toxin
HTZ78_RS00920 (HTZ78_00920) 176409..177377 - 969 WP_212718064.1 carbon-nitrogen hydrolase family protein -
HTZ78_RS00925 (HTZ78_00925) 177405..178211 - 807 WP_212718065.1 urease accessory protein UreD -
HTZ78_RS00930 (HTZ78_00930) 178204..178386 + 183 WP_212718066.1 hypothetical protein -
HTZ78_RS00935 (HTZ78_00935) 178474..178923 - 450 WP_212718067.1 photosystem II protein PsbQ -
HTZ78_RS00940 (HTZ78_00940) 179230..180126 + 897 WP_212718068.1 prohibitin family protein -
HTZ78_RS00945 (HTZ78_00945) 180236..180757 - 522 WP_212718069.1 gamma carbonic anhydrase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 172675..182220 9545


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(1-78)

Antitoxin

Protein of unknown function DUF433

(9-63)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12438.38 Da        Isoelectric Point: 4.3410

>T159399 WP_190599655.1 NZ_CP054306:175947-176285 [Synechocystis sp. PCC 7338]
MNIWVDAQLPPTLADWLSSSFDLEAAALRDLGLRDAKDIEIFDAARVANSVIMTKDSDFVDLVCRLGIPPQIIWLTCGNV
TNRNLRRILSSTLPKALEKLQEGEMIVEISSP

Download         Length: 339 bp

>T159399 NZ_CP070041:1782089-1782307 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8194.48 Da        Isoelectric Point: 4.4013

>AT159399 WP_212718063.1 NZ_CP054306:175726-175950 [Synechocystis sp. PCC 7338]
MNSLLSRVTQIPGQCGGRPCIRGMRIRVSDILEMLAENVSTSEILEDFPDLEIADIQACLVFAARRTDFPQLTA

Download         Length: 225 bp

>AT159399 NZ_CP070041:1781689-1782063 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References