Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5021086..5021602 Replicon chromosome
Accession NZ_CP054303
Organism Klebsiella pneumoniae strain MS14393

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag MS14393_RS24750 Protein ID WP_002886902.1
Coordinates 5021318..5021602 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MS14393_RS24745 Protein ID WP_002886901.1
Coordinates 5021086..5021328 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS14393_RS24730 5017114..5017854 + 741 WP_040147051.1 KDGP aldolase family protein -
MS14393_RS24735 5017921..5019075 + 1155 WP_002886900.1 lactonase family protein -
MS14393_RS24740 5019098..5021008 + 1911 WP_040147048.1 BglG family transcription antiterminator -
MS14393_RS24745 5021086..5021328 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MS14393_RS24750 5021318..5021602 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MS14393_RS24755 5021606..5022070 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MS14393_RS24760 5022378..5024516 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
MS14393_RS24765 5024873..5025616 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MS14393_RS24770 5025619..5025792 - 174 WP_004222159.1 hypothetical protein -
MS14393_RS24775 5025877..5026185 + 309 WP_004178377.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T159394 WP_002886902.1 NZ_CP054303:5021318-5021602 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T159394 NZ_CP070041:424923-425025 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT159394 WP_002886901.1 NZ_CP054303:5021086-5021328 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT159394 NZ_CP070041:c425063-424795 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References