Detailed information of TA system TA159390

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3679247..3679904
• Replicon: chromosome
• Accession: NZ_CP054303
• Organism: Klebsiella pneumoniae strain MS14393

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MS14393_RS18210
• Protein ID: WP_173819993.1
• Coordinates: 3679247..3679657 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: MS14393_RS18215
• Protein ID: WP_002916312.1
• Coordinates: 3679638..3679904 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MS14393_RS18190	3675247..3676980	-	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-
MS14393_RS18195	3676986..3677699	-	714	WP_004185548.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
MS14393_RS18200	3677722..3678618	-	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
MS14393_RS18205	3678719..3679240	+	522	WP_004144730.1	flavodoxin FldB	-
MS14393_RS18210	3679247..3679657	-	411	WP_173819993.1	protein YgfX	Toxin
MS14393_RS18215	3679638..3679904	-	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
MS14393_RS18220	3680150..3681133	+	984	WP_002916313.1	tRNA-modifying protein YgfZ	-
MS14393_RS18225	3681284..3681943	-	660	WP_002916317.1	hemolysin III family protein	-
MS14393_RS18230	3682107..3682418	-	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
MS14393_RS18235	3682468..3683196	+	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
MS14393_RS18240	3683315..3684748	+	1434	WP_040219565.1	6-phospho-beta-glucosidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16026.82 Da
• Isoelectric Point: 11.4778

>T159390 WP_173819993.1 NZ_CP054303:c3679657-3679247 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPVWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRQVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T159390 NZ_CP070039:c90875-90459 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT159390 WP_002916312.1 NZ_CP054303:c3679904-3679638 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT159390 NZ_CP070039:c91102-90872 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41