Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 3303065..3303723 Replicon chromosome
Accession NZ_CP054303
Organism Klebsiella pneumoniae strain MS14393

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag MS14393_RS16390 Protein ID WP_103766787.1
Coordinates 3303403..3303723 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag MS14393_RS16385 Protein ID WP_109610586.1
Coordinates 3303065..3303382 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS14393_RS16340 3298206..3299030 + 825 WP_151425516.1 DUF945 domain-containing protein -
MS14393_RS16345 3299239..3299949 + 711 WP_151425515.1 DeoR family transcriptional regulator -
MS14393_RS16350 3299975..3300511 + 537 WP_151425514.1 DUF4339 domain-containing protein -
MS14393_RS16355 3300553..3300990 + 438 WP_165707987.1 hypothetical protein -
MS14393_RS16360 3301057..3301467 + 411 WP_151425512.1 hypothetical protein -
MS14393_RS16365 3301545..3301781 + 237 WP_151425511.1 DUF905 domain-containing protein -
MS14393_RS16370 3301867..3302325 + 459 WP_109610580.1 antirestriction protein -
MS14393_RS16375 3302334..3302816 + 483 WP_109610582.1 RadC family protein -
MS14393_RS16380 3302825..3303046 + 222 WP_000691995.1 DUF987 domain-containing protein -
MS14393_RS16385 3303065..3303382 + 318 WP_109610586.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MS14393_RS16390 3303403..3303723 + 321 WP_103766787.1 TA system toxin CbtA family protein Toxin
MS14393_RS16395 3304154..3304954 - 801 WP_004180956.1 hypothetical protein -
MS14393_RS16400 3305079..3305963 - 885 WP_002914178.1 LysR family transcriptional regulator -
MS14393_RS16405 3306175..3306747 + 573 WP_004212922.1 flavin reductase -
MS14393_RS16410 3306758..3307120 - 363 WP_173820043.1 helix-turn-helix domain-containing protein -
MS14393_RS16415 3307454..3308629 + 1176 WP_002914189.1 multidrug efflux RND transporter periplasmic adaptor subunit OqxA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-104)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12097.07 Da        Isoelectric Point: 7.2776

>T159389 WP_103766787.1 NZ_CP054303:3303403-3303723 [Klebsiella pneumoniae]
MKTLPATTLRAAKPCPSPVIVWQMLLSRLLDQHYGLTLNDTPFSDETVIKEHIDAGISLADAVNFLVEKYELVRIDHKGF
SWQEQSPFITAVDILKARRAMREMRT

Download         Length: 321 bp

>T159389 NZ_CP070038:152862-153332 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACAGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGACAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12057.64 Da        Isoelectric Point: 6.6255

>AT159389 WP_109610586.1 NZ_CP054303:3303065-3303382 [Klebsiella pneumoniae]
MSNITWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDVECRKLDETFPHFISQMESMLTTEELNSRHTHCVILYH
NGFTCEADTLGSCGYVYITVYPTQR

Download         Length: 318 bp

>AT159389 NZ_CP070038:152422-152865 [Klebsiella pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAAGTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGTGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTTATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACTGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References