Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 624419..625070 Replicon chromosome
Accession NZ_CP054302
Organism Acinetobacter baumannii strain MS14413

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag MS14413_RS02965 Protein ID WP_000838146.1
Coordinates 624888..625070 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag MS14413_RS02960 Protein ID WP_000966689.1
Coordinates 624419..624823 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS14413_RS02950 619740..623708 - 3969 WP_000191303.1 tape measure protein -
MS14413_RS02955 623805..624323 - 519 WP_053530939.1 DUF4468 domain-containing protein -
MS14413_RS02960 624419..624823 - 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MS14413_RS02965 624888..625070 - 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
MS14413_RS02970 625402..625935 - 534 WP_001185622.1 hypothetical protein -
MS14413_RS02975 625980..626909 - 930 WP_000094300.1 hypothetical protein -
MS14413_RS02980 627018..627230 - 213 WP_000121166.1 hypothetical protein -
MS14413_RS02985 627232..627630 - 399 WP_001132270.1 hypothetical protein -
MS14413_RS02990 627632..628000 - 369 WP_000539752.1 hypothetical protein -
MS14413_RS02995 627972..628376 - 405 WP_000248324.1 hypothetical protein -
MS14413_RS03000 628385..628798 - 414 WP_001197735.1 hypothetical protein -
MS14413_RS03005 628755..629144 - 390 WP_032041498.1 hypothetical protein -
MS14413_RS03010 629149..629814 - 666 WP_000767881.1 stress-responsive nuclear envelope protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 604492..655393 50901


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T159377 WP_000838146.1 NZ_CP054302:c625070-624888 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T159377 NZ_CP070035:c740-480 [Escherichia coli]
ATGAAAATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCTGATCTTGTTTTTAATGAGAAGGCAT
TCGACACAATAGACTTTTCCAGAGATGGATTAAGAGAGAATGATAAAGATATTGTTTTTATGATGATTCAGGAAATGAGC
GAGGGAAAAAATGCTAAATGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT159377 WP_000966689.1 NZ_CP054302:c624823-624419 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT159377 NZ_CP070035:c490-239 [Escherichia coli]
ATGCTAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTCAGCATGAGTCCGCGTACATGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTCCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References