Detailed information of TA system TA159375

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 2476196..2476752
• Replicon: chromosome
• Accession: NZ_CP054301
• Organism: Marinomonas primoryensis strain MPKMM3633

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MP3633_RS11480
• Protein ID: WP_176335647.1
• Coordinates: 2476196..2476507 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MP3633_RS11485
• Protein ID: WP_176335648.1
• Coordinates: 2476495..2476752 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MP3633_RS11460	2471567..2473576	-	2010	WP_176335644.1	EAL domain-containing protein	-
MP3633_RS11465	2473638..2474501	-	864	WP_176335645.1	DUF1853 family protein	-
MP3633_RS11470	2474498..2474839	-	342	WP_176335646.1	YqcC family protein	-
MP3633_RS11475	2474953..2476023	+	1071	WP_176336793.1	DUF3549 family protein	-
MP3633_RS11480	2476196..2476507	-	312	WP_176335647.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MP3633_RS11485	2476495..2476752	-	258	WP_176335648.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MP3633_RS11490	2476857..2477579	-	723	WP_176335649.1	DUF4365 domain-containing protein	-
MP3633_RS11495	2477697..2479424	-	1728	WP_176335650.1	ATP-binding protein	-
MP3633_RS11500	2479434..2480447	-	1014	WP_176336794.1	SIR2 family protein	-
MP3633_RS11505	2480624..2480956	-	333	WP_176335651.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-70)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12155.82 Da
• Isoelectric Point: 4.8604

>T159375 WP_176335647.1 NZ_CP054301:c2476507-2476196 [Marinomonas primoryensis]
MAQIIWTEPALNNLNDIAEYIAVSNPYAARQLVERVFSKVQRLEQFPDSGRIPEEISTLNYREVVVNPCRIFYKVDNDSI
YILHLLRQERDLRKFLLSTENEN

Nucleotide

• Length: 312 bp

>T159375 NZ_CP070027:c15527-15240 [Escherichia coli]
ATGACTTATACAGTAAAATTCCGGGATGATGCACTGAAAGAATGGCTCAGACTGGACAAGACCATTCAGCAGCAGTTCGC
AAAAAAACTGAAAAAATGCAGTGAAAATCCTCATATAGCTTCTGCAAAACTACGTGGATTAAAGGACTGCTATAAAATCA
AACTTCGCGCATCAGGTTTTCGTCTGGTTTATCAGGTTATTGATGATATGTTAATTATTGCGGTCGTCGCAGTAGGTAAA
CGTGAACGCAGCAACGTTTATCATCTCGCCAGTGAACGGATGAAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9822.51 Da
• Isoelectric Point: 8.5159

>AT159375 WP_176335648.1 NZ_CP054301:c2476752-2476495 [Marinomonas primoryensis]
MRTEVVTTLKRQATKLLADLRESKEPILITEHGQPSAYLLDVADYELMLERMKILEGIAKGEQSIREGRTMDMTQAKEKM
SKWLK

Nucleotide

• Length: 258 bp

>AT159375 NZ_CP070027:c15775-15524 [Escherichia coli]
ATGCCCAGTATCATTTTGTCTGACACCAGTGCAAGCGTCAGTGAGCTGAAAAAAAATCCGATGGCAACTGTCAGTGCCGG
AGAGGGGTATCCTGTTGCCATTCTTAACCGGAATCAGCCAGCATTCTACTGTGTCCCTGCTGAGCTCTATGAAAGAATGC
TTGATGCCTTGGATGACCAGGAGCTGGTAAAACTGGTTACTGAACGCAGCAGTCAGCCTCTGCATGATGTGGACCTGGAC
AGTTATTTATGA