159367

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4647485..4648151 Replicon chromosome
Accession NZ_CP054294
Organism Citrobacter freundii strain IDR1800045912-01-00

Toxin (Protein)


Gene name tad Uniprot ID A0A0D7LIM5
Locus tag HS089_RS22385 Protein ID WP_044702260.1
Coordinates 4647792..4648151 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A0D7LIR0
Locus tag HS089_RS22380 Protein ID WP_003844682.1
Coordinates 4647485..4647802 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HS089_RS22350 4643152..4643976 + 825 WP_003031641.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HS089_RS22355 4644045..4645268 + 1224 WP_044702265.1 L-sorbose 1-phosphate reductase -
HS089_RS22360 4645270..4646082 + 813 WP_044702264.1 shikimate 5-dehydrogenase -
HS089_RS22365 4646134..4646490 - 357 WP_032948294.1 hypothetical protein -
HS089_RS22370 4646632..4646793 + 162 WP_003841416.1 phage protein -
HS089_RS22375 4647197..4647475 + 279 WP_044702262.1 putative addiction module antidote protein -
HS089_RS22380 4647485..4647802 - 318 WP_003844682.1 helix-turn-helix domain-containing protein Antitoxin
HS089_RS22385 4647792..4648151 - 360 WP_044702260.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HS089_RS22390 4648365..4649054 + 690 WP_003841421.1 dipeptidase PepE -
HS089_RS22395 4649120..4650751 - 1632 WP_032938230.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13437.49 Da        Isoelectric Point: 10.2555

>T159367 WP_044702260.1 NZ_CP054294:c4648151-4647792 [Citrobacter freundii]
MTKPLYWVGQARKDLIAMPEHVRDTFGFALWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGNAWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAAQRHAQESGYVT

Download         Length: 360 bp

>T159367 NZ_CP070026:c3067993-3067886 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11466.35 Da        Isoelectric Point: 9.0005

>AT159367 WP_003844682.1 NZ_CP054294:c4647802-4647485 [Citrobacter freundii]
MSHDVETSSGNVYADLGAYDAEQMQLKAQLAMVIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGKEGNMSGKLKVKFG

Download         Length: 318 bp

>AT159367 NZ_CP070026:3068040-3068106 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7LIM5

Antitoxin

Source ID Structure
AlphaFold DB A0A0D7LIR0

References