Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4391352..4391868 Replicon chromosome
Accession NZ_CP054294
Organism Citrobacter freundii strain IDR1800045912-01-00

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HS089_RS21165 Protein ID WP_044699148.1
Coordinates 4391352..4391636 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0J1MV10
Locus tag HS089_RS21170 Protein ID WP_003839576.1
Coordinates 4391626..4391868 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HS089_RS21150 4387677..4388261 + 585 WP_003839584.1 fructose PTS transporter subunit IIA -
HS089_RS21155 4388639..4390777 + 2139 WP_003025782.1 anaerobic ribonucleoside-triphosphate reductase -
HS089_RS21160 4390884..4391348 + 465 WP_032937736.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HS089_RS21165 4391352..4391636 - 285 WP_044699148.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HS089_RS21170 4391626..4391868 - 243 WP_003839576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HS089_RS21175 4391946..4393859 - 1914 WP_003839574.1 BglG family transcription antiterminator -
HS089_RS21180 4393881..4394621 - 741 WP_044699149.1 KDGP aldolase family protein -
HS089_RS21185 4394618..4395736 - 1119 WP_044699152.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
HS089_RS21190 4395720..4396853 - 1134 WP_016149471.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10865.69 Da        Isoelectric Point: 10.1988

>T159366 WP_044699148.1 NZ_CP054294:c4391636-4391352 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVTVFVVAVGK
RQHSAVYLDANKRL

Download         Length: 285 bp

>T159366 NZ_CP070026:c3067458-3067351 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT159366 WP_003839576.1 NZ_CP054294:c4391868-4391626 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp

>AT159366 NZ_CP070026:3067505-3067571 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MV10

References