Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 67062..67587 Replicon plasmid p3K157
Accession NZ_CP054287
Organism Klebsiella pneumoniae strain IDR1800050501-01-02

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag HS091_RS26900 Protein ID WP_012539978.1
Coordinates 67062..67367 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID R4WC25
Locus tag HS091_RS26905 Protein ID WP_015632547.1
Coordinates 67369..67587 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HS091_RS26875 62951..63706 - 756 WP_012539983.1 replication initiation protein RepE -
HS091_RS26880 64338..64451 + 114 WP_032072094.1 hypothetical protein -
HS091_RS26885 64579..64836 + 258 WP_032433931.1 hypothetical protein -
HS091_RS26890 64894..65673 - 780 WP_015632549.1 site-specific integrase -
HS091_RS26895 65871..66875 - 1005 WP_029497484.1 hypothetical protein -
HS091_RS26900 67062..67367 - 306 WP_012539978.1 type II toxin-antitoxin system toxin CcdB Toxin
HS091_RS26905 67369..67587 - 219 WP_015632547.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
HS091_RS26910 68187..69461 + 1275 WP_015632546.1 hypothetical protein -
HS091_RS26915 69534..69719 - 186 WP_032433930.1 hypothetical protein -
HS091_RS26920 70297..70647 + 351 WP_015632544.1 hypothetical protein -
HS091_RS26925 70840..72342 - 1503 WP_048296350.1 RES family NAD+ phosphorylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aac(3)-IIa / blaOXA-1 / aac(6')-Ib-cr / blaCTX-M-15 / blaTEM-1B / aph(6)-Id / aph(3'')-Ib / sul2 / dfrA14 / qnrB1 / tet(A) - 1..156980 156980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11601.27 Da        Isoelectric Point: 6.4661

>T159351 WP_012539978.1 NZ_CP054287:c67367-67062 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDDSYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T159351 NZ_CP070020:c3458883-3458780 [Klebsiella oxytoca]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTTTTTTT

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8362.31 Da        Isoelectric Point: 4.7247

>AT159351 WP_015632547.1 NZ_CP054287:c67587-67369 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRAERWQAENQEGMAEVARFIDMNGSFADENRDW

Download         Length: 219 bp

>AT159351 NZ_CP070020:3458773-3458918 [Klebsiella oxytoca]
AAAAGATAAAAAAAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTTACCGTGTCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1KT86

References