Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 92861..93515 Replicon chromosome
Accession NZ_CP054278
Organism Citrobacter freundii strain IDR1900015725-01-02

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag HS092_RS00480 Protein ID WP_003026936.1
Coordinates 93108..93515 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag HS092_RS00475 Protein ID WP_003026938.1
Coordinates 92861..93127 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HS092_RS00450 88061..89494 - 1434 WP_003846391.1 6-phospho-beta-glucosidase BglA -
HS092_RS00455 89616..90344 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
HS092_RS00460 90397..90708 + 312 WP_003026949.1 N(4)-acetylcytidine aminohydrolase -
HS092_RS00465 90871..91530 + 660 WP_003838267.1 hemolysin III family protein -
HS092_RS00470 91624..92604 - 981 WP_048232745.1 tRNA-modifying protein YgfZ -
HS092_RS00475 92861..93127 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
HS092_RS00480 93108..93515 + 408 WP_003026936.1 protein YgfX Toxin
HS092_RS00485 93560..94081 - 522 WP_003026933.1 flavodoxin FldB -
HS092_RS00490 94195..95091 + 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
HS092_RS00495 95115..95828 + 714 WP_003026923.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HS092_RS00500 95834..97567 + 1734 WP_048232743.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T159294 WP_003026936.1 NZ_CP054278:93108-93515 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

>T159294 NZ_CP069996:2476596-2476703 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT159294 WP_003026938.1 NZ_CP054278:92861-93127 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT159294 NZ_CP069996:c2476539-2476482 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References