Detailed information of TA system TA159285

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 4779890..4780415
• Replicon: chromosome
• Accession: NZ_CP054277
• Organism: Serratia marcescens strain Byron

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HS042_RS22635
• Protein ID: WP_015377296.1
• Coordinates: 4779890..4780174 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8B4GIN1
• Locus tag: HS042_RS22640
• Protein ID: WP_004928423.1
• Coordinates: 4780164..4780415 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HS042_RS22610	4775150..4776283	+	1134	WP_004938650.1	putrescine ABC transporter ATP-binding subunit PotG	-
HS042_RS22615	4776308..4777270	+	963	WP_021504359.1	putrescine ABC transporter permease PotH	-
HS042_RS22620	4777267..4778112	+	846	WP_004938644.1	putrescine ABC transporter permease PotI	-
HS042_RS22625	4778217..4778696	+	480	WP_160125301.1	YbjO family protein	-
HS042_RS22630	4778766..4779893	+	1128	WP_015377295.1	23S rRNA (uracil(747)-C(5))-methyltransferase RlmC	-
HS042_RS22635	4779890..4780174	-	285	WP_015377296.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HS042_RS22640	4780164..4780415	-	252	WP_004928423.1	prevent-host-death protein	Antitoxin
HS042_RS22645	4780517..4781251	-	735	WP_015377297.1	arginine ABC transporter substrate-binding protein	-
HS042_RS22650	4781450..4782118	-	669	WP_015377298.1	arginine ABC transporter permease ArtM	-
HS042_RS22655	4782118..4782834	-	717	WP_004928413.1	arginine ABC transporter permease ArtQ	-
HS042_RS22660	4782844..4783575	-	732	WP_004928409.1	arginine ABC transporter substrate-binding protein	-
HS042_RS22665	4783608..4784336	-	729	WP_004928406.1	arginine ABC transporter ATP-binding protein ArtP	-
HS042_RS22670	4784599..4785141	-	543	WP_015377301.1	lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10803.94 Da
• Isoelectric Point: 10.6941

>T159285 WP_015377296.1 NZ_CP054277:c4780174-4779890 [Serratia marcescens]
MTYKLEFEEHALKEFKKLSPVIREQFKKKLASVLVNPHIPANKLAGLPDCYKIKLRASGFRLVYRVMETEIVVLVLSVGK
RERSAAYTAAKKRL

Nucleotide

• Length: 285 bp

>T159285 NZ_CP069996:705053-705271 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9108.39 Da
• Isoelectric Point: 4.5203

>AT159285 WP_004928423.1 NZ_CP054277:c4780415-4780164 [Serratia marcescens]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDIELAEIVRSRMNGKRIKVNL
DDL

Nucleotide

• Length: 252 bp

>AT159285 NZ_CP069996:704653-705027 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A8B4GIN1