Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4651193..4651740 Replicon chromosome
Accession NZ_CP054277
Organism Serratia marcescens strain Byron

Toxin (Protein)


Gene name ccdB Uniprot ID A0A1Q4P6P4
Locus tag HS042_RS22085 Protein ID WP_073528876.1
Coordinates 4651432..4651740 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0G3SUU9
Locus tag HS042_RS22080 Protein ID WP_033633717.1
Coordinates 4651193..4651429 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HS042_RS22065 4647679..4649214 + 1536 WP_004938996.1 glutathione ABC transporter substrate-binding protein GsiB -
HS042_RS22070 4649267..4650187 + 921 WP_004938995.1 glutathione ABC transporter permease GsiC -
HS042_RS22075 4650197..4651117 + 921 WP_174242101.1 glutathione ABC transporter permease GsiD -
HS042_RS22080 4651193..4651429 + 237 WP_033633717.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
HS042_RS22085 4651432..4651740 + 309 WP_073528876.1 CcdB family protein Toxin
HS042_RS22090 4651777..4652619 - 843 WP_015377214.1 S-formylglutathione hydrolase -
HS042_RS22095 4652634..4653758 - 1125 WP_076740425.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
HS042_RS22100 4653788..4654708 - 921 WP_004938975.1 LysR family transcriptional regulator -
HS042_RS22105 4654814..4655971 + 1158 WP_004938972.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11448.21 Da        Isoelectric Point: 5.0196

>T159284 WP_073528876.1 NZ_CP054277:4651432-4651740 [Serratia marcescens]
MQFTVYDNTYPASAYPYLLDVQSDLIDALSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQIGKA
VGNANEHRNQIKAAIDFLIDGF

Download         Length: 309 bp

>T159284 NZ_CP069996:c675931-675629 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATTGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8994.07 Da        Isoelectric Point: 5.0807

>AT159284 WP_033633717.1 NZ_CP054277:4651193-4651429 [Serratia marcescens]
MANNNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Download         Length: 237 bp

>AT159284 NZ_CP069996:c675593-675252 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4P6P4

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3SUU9

References