Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4141810..4142431 Replicon chromosome
Accession NZ_CP054277
Organism Serratia marcescens strain Byron

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag HS042_RS19575 Protein ID WP_004940313.1
Coordinates 4141810..4142013 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag HS042_RS19580 Protein ID WP_004940312.1
Coordinates 4142063..4142431 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HS042_RS19545 4137509..4137847 + 339 WP_004940327.1 P-II family nitrogen regulator -
HS042_RS19550 4137884..4139170 + 1287 WP_004940322.1 ammonium transporter AmtB -
HS042_RS19555 4139261..4140124 - 864 WP_015376854.1 acyl-CoA thioesterase II -
HS042_RS19560 4140356..4140847 + 492 WP_015376855.1 YbaY family lipoprotein -
HS042_RS19565 4140912..4141226 - 315 WP_015376856.1 MGMT family protein -
HS042_RS19575 4141810..4142013 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
HS042_RS19580 4142063..4142431 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
HS042_RS19585 4142590..4142943 - 354 WP_004940311.1 hypothetical protein -
HS042_RS19590 4143347..4144060 + 714 WP_049242873.1 ABC transporter ATP-binding protein -
HS042_RS19595 4144057..4144914 + 858 WP_015376858.1 metal ABC transporter permease -
HS042_RS19600 4144940..4145818 + 879 WP_160125149.1 metal ABC transporter substrate-binding protein -
HS042_RS19605 4145925..4146065 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
HS042_RS19610 4146078..4146332 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T159283 WP_004940313.1 NZ_CP054277:c4142013-4141810 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T159283 NZ_CP069995:121188-121670 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT159283 WP_004940312.1 NZ_CP054277:c4142431-4142063 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT159283 NZ_CP069995:120934-121200 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References