Detailed information of TA system TA159282

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2710970..2711706
• Replicon: chromosome
• Accession: NZ_CP054277
• Organism: Serratia marcescens strain Byron

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HS042_RS12920
• Protein ID: WP_076741273.1
• Coordinates: 2711227..2711706 (+)
• Length: 160 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A5C7DAD3
• Locus tag: HS042_RS12915
• Protein ID: WP_015379309.1
• Coordinates: 2710970..2711230 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HS042_RS12895	2707040..2707720	+	681	WP_004930298.1	GMP/IMP nucleotidase	-
HS042_RS12900	2707717..2708124	+	408	WP_015379306.1	ribosome-associated heat shock protein Hsp15	-
HS042_RS12905	2708150..2709028	+	879	WP_015379307.1	Hsp33 family molecular chaperone HslO	-
HS042_RS12910	2709223..2710842	+	1620	WP_015379308.1	phosphoenolpyruvate carboxykinase (ATP)	-
HS042_RS12915	2710970..2711230	+	261	WP_015379309.1	plasmid stability-like protein	Antitoxin
HS042_RS12920	2711227..2711706	+	480	WP_076741273.1	type II toxin-antitoxin system VapC family toxin	Toxin
HS042_RS12925	2711739..2713109	-	1371	WP_015379311.1	two-component system sensor histidine kinase EnvZ	-
HS042_RS12930	2713106..2713825	-	720	WP_004709363.1	two-component system response regulator OmpR	-
HS042_RS12935	2714083..2714388	-	306	WP_004930739.1	chaperone-modulator protein CbpM	-
HS042_RS12940	2714394..2715356	-	963	WP_015379312.1	curved DNA-binding protein	-
HS042_RS12945	2715586..2716059	+	474	WP_004930745.1	transcription elongation factor GreB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 160 a.a.
• Molecular weight: 18028.66 Da
• Isoelectric Point: 5.9070

>T159282 WP_076741273.1 NZ_CP054277:2711227-2711706 [Serratia marcescens]
MIVLDTNVVSELLRPAPHYNVLRWLDEQDTYRFYLSAIVVAELYTGIACMPHGKKQLELQTNLGDMLQEEFSDRILPFDV
GCAMQHAELMGANRRRGIGVSMPDTQIAATCLHYGATLATRNTKDFLHCGIELIDPWQAPTGRRLHEDAAEYYVMSRKS

Nucleotide

• Length: 480 bp

>T159282 NZ_CP069994:5025894-5026427 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9907.29 Da
• Isoelectric Point: 5.1898

>AT159282 WP_015379309.1 NZ_CP054277:2710970-2711230 [Serratia marcescens]
MATITVRNLDDEIKELLRISAAKNGHSMEEEARMILKQALVKKPPRYGLGTRMHQYFAEFGGVELEIPPRDEAPHRIVNF
DEDDEK

Nucleotide

• Length: 261 bp

>AT159282 NZ_CP069994:5025617-5025883 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A5C7DAD3