Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2139189..2139858 Replicon chromosome
Accession NZ_CP054277
Organism Serratia marcescens strain Byron

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag HS042_RS10165 Protein ID WP_004931681.1
Coordinates 2139189..2139611 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8G2G4M4
Locus tag HS042_RS10170 Protein ID WP_004931679.1
Coordinates 2139592..2139858 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HS042_RS10145 2135118..2136851 - 1734 WP_033639478.1 single-stranded-DNA-specific exonuclease RecJ -
HS042_RS10150 2136858..2137574 - 717 WP_004931688.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HS042_RS10155 2137601..2138500 - 900 WP_004931685.1 site-specific tyrosine recombinase XerD -
HS042_RS10160 2138607..2139125 + 519 WP_160125917.1 flavodoxin FldB -
HS042_RS10165 2139189..2139611 - 423 WP_004931681.1 protein YgfX Toxin
HS042_RS10170 2139592..2139858 - 267 WP_004931679.1 FAD assembly factor SdhE Antitoxin
HS042_RS10175 2140179..2141171 + 993 WP_160125918.1 tRNA-modifying protein YgfZ -
HS042_RS10180 2141210..2141707 - 498 WP_044030541.1 DUF2165 domain-containing protein -
HS042_RS10185 2141858..2142532 - 675 WP_021505704.1 hemolysin III family protein -
HS042_RS10190 2142716..2143324 + 609 WP_004931670.1 HD domain-containing protein -
HS042_RS10195 2143365..2144291 - 927 WP_015378971.1 ribokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2135889..2208282 72393


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16487.59 Da        Isoelectric Point: 11.0198

>T159279 WP_004931681.1 NZ_CP054277:c2139611-2139189 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEQG

Download         Length: 423 bp

>T159279 NZ_CP069994:4436633-4437016 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10387.89 Da        Isoelectric Point: 4.7921

>AT159279 WP_004931679.1 NZ_CP054277:c2139858-2139592 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT159279 NZ_CP069994:4436391-4436633 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References