Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1661431..1661993 Replicon chromosome
Accession NZ_CP054277
Organism Serratia marcescens strain Byron

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag HS042_RS07920 Protein ID WP_044030725.1
Coordinates 1661431..1661787 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag HS042_RS07925 Protein ID WP_004936539.1
Coordinates 1661784..1661993 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HS042_RS07900 1657167..1657964 - 798 WP_021505631.1 energy transducer TonB -
HS042_RS07905 1658067..1658906 - 840 WP_015378685.1 ChaN family lipoprotein -
HS042_RS07910 1659084..1660493 + 1410 WP_015378686.1 S-methylmethionine permease -
HS042_RS07915 1660483..1661421 + 939 WP_021505634.1 homocysteine S-methyltransferase -
HS042_RS07920 1661431..1661787 - 357 WP_044030725.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HS042_RS07925 1661784..1661993 - 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HS042_RS07930 1662103..1664382 - 2280 WP_004936542.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
HS042_RS07935 1664597..1664770 - 174 WP_165385135.1 hypothetical protein -
HS042_RS07940 1664751..1665131 - 381 WP_160125680.1 DUF2570 family protein -
HS042_RS07945 1665128..1665529 - 402 WP_033643981.1 M15 family metallopeptidase -
HS042_RS07950 1665519..1665845 - 327 WP_004936551.1 phage holin, lambda family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(27-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13154.92 Da        Isoelectric Point: 4.7274

>T159276 WP_044030725.1 NZ_CP054277:c1661787-1661431 [Serratia marcescens]
MIFLTAEDIAEFNAEIVPHGRQEGSKVEAVANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEQLRRLTE

Download         Length: 357 bp

>T159276 NZ_CP069994:c2412685-2412583 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT159276 WP_004936539.1 NZ_CP054277:c1661993-1661784 [Serratia marcescens]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp

>AT159276 NZ_CP069994:2412576-2412721 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References