Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 2312227..2313140 | Replicon | chromosome |
| Accession | NZ_CP054270 | ||
| Organism | Raoultella ornithinolytica strain OHMEATKPC2_NDM5 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A808Y4A8 |
| Locus tag | HRV96_RS10835 | Protein ID | WP_015584188.1 |
| Coordinates | 2312227..2312700 (-) | Length | 158 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A808Y7A4 |
| Locus tag | HRV96_RS10840 | Protein ID | WP_004862777.1 |
| Coordinates | 2312697..2313140 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HRV96_RS10810 (HRV96_10780) | 2308266..2308874 | - | 609 | WP_032716409.1 | glutathione S-transferase family protein | - |
| HRV96_RS10815 (HRV96_10785) | 2309116..2310021 | + | 906 | WP_104897325.1 | LysR substrate-binding domain-containing protein | - |
| HRV96_RS10820 (HRV96_10790) | 2310049..2310954 | - | 906 | WP_234972223.1 | LysR family transcriptional regulator | - |
| HRV96_RS10825 (HRV96_10795) | 2311057..2311374 | + | 318 | WP_004862785.1 | nuclear transport factor 2 family protein | - |
| HRV96_RS10830 (HRV96_10800) | 2311367..2312146 | + | 780 | WP_044349850.1 | SDR family oxidoreductase | - |
| HRV96_RS10835 (HRV96_10805) | 2312227..2312700 | - | 474 | WP_015584188.1 | RES domain-containing protein | Toxin |
| HRV96_RS10840 (HRV96_10810) | 2312697..2313140 | - | 444 | WP_004862777.1 | DUF2384 domain-containing protein | Antitoxin |
| HRV96_RS10845 (HRV96_10815) | 2313330..2313884 | - | 555 | WP_234972224.1 | DJ-1/PfpI family protein | - |
| HRV96_RS10850 (HRV96_10820) | 2314074..2315255 | + | 1182 | WP_234972225.1 | site-specific integrase | - |
| HRV96_RS10855 (HRV96_10825) | 2315236..2315427 | - | 192 | WP_025714666.1 | hypothetical protein | - |
| HRV96_RS10860 (HRV96_10830) | 2315438..2315584 | - | 147 | WP_032419897.1 | hypothetical protein | - |
| HRV96_RS10865 (HRV96_10835) | 2315581..2315805 | - | 225 | WP_025714667.1 | hypothetical protein | - |
| HRV96_RS10870 (HRV96_10840) | 2315789..2316226 | - | 438 | WP_117032783.1 | hypothetical protein | - |
| HRV96_RS10875 (HRV96_10845) | 2316216..2316971 | - | 756 | WP_117032738.1 | ORF6N domain-containing protein | - |
| HRV96_RS10880 (HRV96_10850) | 2316974..2317210 | - | 237 | WP_142305689.1 | hypothetical protein | - |
| HRV96_RS10885 (HRV96_10855) | 2317223..2317741 | - | 519 | WP_234972267.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2309116..2349345 | 40229 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 158 a.a. Molecular weight: 17524.82 Da Isoelectric Point: 4.8081
>T159268 WP_015584188.1 NZ_CP054270:c2312700-2312227 [Raoultella ornithinolytica]
MIFYRLVTGRYASEAWTGSGANQYGGRWNHQGHPAVYVSTSIALASLEILVHVKNEAILNQYQLYSIEIPDSEVESLDKQ
WLPDNWQENPMPVSTMDLGTGWLQSGSGLALMLPSCIIPYENNAILNPLHPAFSEALASVRQYPFTFDPRLARSTPL
MIFYRLVTGRYASEAWTGSGANQYGGRWNHQGHPAVYVSTSIALASLEILVHVKNEAILNQYQLYSIEIPDSEVESLDKQ
WLPDNWQENPMPVSTMDLGTGWLQSGSGLALMLPSCIIPYENNAILNPLHPAFSEALASVRQYPFTFDPRLARSTPL
Download Length: 474 bp
>T159268 NZ_CP069992:4315564-4315947 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCATCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCATCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
Antitoxin
Download Length: 148 a.a. Molecular weight: 16190.45 Da Isoelectric Point: 4.9405
>AT159268 WP_004862777.1 NZ_CP054270:c2313140-2312697 [Raoultella ornithinolytica]
MKTWVPAEQPADNALWRYAGLPANRGMQLIELLSMGLPVSILDNIHEWTEMSKTDILRITGINERNVARRKSAGGTLTPG
ESERVARFVRVLDTAVDYFGSKQDAYDWLQSPVRGLGNVAPIDLIATESGALEVTDLIGRLEHGVFA
MKTWVPAEQPADNALWRYAGLPANRGMQLIELLSMGLPVSILDNIHEWTEMSKTDILRITGINERNVARRKSAGGTLTPG
ESERVARFVRVLDTAVDYFGSKQDAYDWLQSPVRGLGNVAPIDLIATESGALEVTDLIGRLEHGVFA
Download Length: 444 bp
>AT159268 NZ_CP069992:4315322-4315564 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A808Y4A8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A808Y7A4 |