Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4135348..4135967 Replicon chromosome
Accession NZ_CP054268
Organism Klebsiella pneumoniae strain 39427

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HPS02_RS22505 Protein ID WP_002892050.1
Coordinates 4135749..4135967 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HPS02_RS22500 Protein ID WP_002892066.1
Coordinates 4135348..4135722 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPS02_RS22490 4130500..4131693 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HPS02_RS22495 4131716..4134862 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HPS02_RS22500 4135348..4135722 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HPS02_RS22505 4135749..4135967 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HPS02_RS22510 4136126..4136692 + 567 WP_002892030.1 maltose O-acetyltransferase -
HPS02_RS22515 4136664..4136804 - 141 WP_004147370.1 hypothetical protein -
HPS02_RS22520 4136825..4137295 + 471 WP_002892026.1 YlaC family protein -
HPS02_RS22525 4137270..4138721 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HPS02_RS22530 4138822..4139520 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
HPS02_RS22535 4139517..4139657 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HPS02_RS22540 4139657..4139920 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T159253 WP_002892050.1 NZ_CP054268:4135749-4135967 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T159253 NZ_CP069990:3992166-3992273 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCACGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT159253 WP_002892066.1 NZ_CP054268:4135348-4135722 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT159253 NZ_CP069990:c3992118-3992052 [Escherichia coli]
GGTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References