Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2777567..2778126 Replicon chromosome
Accession NZ_CP054258
Organism Treponema socranskii subsp. buccale strain ATCC 35534

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HRI97_RS12460 Protein ID WP_253725830.1
Coordinates 2777567..2777752 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HRI97_RS12465 Protein ID WP_253725832.1
Coordinates 2777749..2778126 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRI97_RS12430 (HRI97_12455) 2773563..2774111 + 549 WP_253725824.1 SIS domain-containing protein -
HRI97_RS12435 (HRI97_12460) 2774147..2774641 + 495 WP_253725826.1 VOC family protein -
HRI97_RS12440 (HRI97_12465) 2774658..2775431 + 774 WP_253725827.1 DeoR/GlpR family DNA-binding transcription regulator -
HRI97_RS12445 (HRI97_12470) 2775464..2775844 - 381 WP_021329701.1 PIN domain-containing protein -
HRI97_RS12450 (HRI97_12475) 2775841..2776038 - 198 WP_021329616.1 type II toxin-antitoxin system VapB family antitoxin -
HRI97_RS12455 (HRI97_12480) 2776253..2777086 - 834 WP_253725828.1 hypothetical protein -
HRI97_RS12460 (HRI97_12485) 2777567..2777752 + 186 WP_253725830.1 type II toxin-antitoxin system HicA family toxin Toxin
HRI97_RS12465 (HRI97_12490) 2777749..2778126 + 378 WP_253725832.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-67)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6642.00 Da        Isoelectric Point: 10.7309

>T159228 WP_253725830.1 NZ_CP054258:2777567-2777752 [Treponema socranskii subsp. buccale]
MKDKDLLKLLLKDGWELVSIRGSHHKLAKGGKTVSVPVHGKDVKKGLLGAILKETGLEVKK

Download         Length: 186 bp

>T159228 NZ_CP069980:c4529226-4527904 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAATGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAACCGTTATGCCAGACCGTTATCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTGCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTGTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGCGCAGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTTCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACCGTCGCTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13915.96 Da        Isoelectric Point: 4.5370

>AT159228 WP_253725832.1 NZ_CP054258:2777749-2778126 [Treponema socranskii subsp. buccale]
MKVIYPAIFHAEDGGFWVEFPDLPGCFTQGDTESEAYANAVETMELFLQDDYTIDTLPTVSAANKIKTDKKSFVSLVCGE
FKVNEKAVKKTLTIPFWLNIQAEKAGVNFSQTLQDALCKKLNVVV

Download         Length: 378 bp

>AT159228 NZ_CP069980:c4529492-4529226 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGTCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATCGGTATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTGACAATACCACGC
TGACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References