Detailed information of TA system TA159227

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 2635049..2635634
• Replicon: chromosome
• Accession: NZ_CP054258
• Organism: Treponema socranskii subsp. buccale strain ATCC 35534

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HRI97_RS11825
• Protein ID: WP_253725669.1
• Coordinates: 2635326..2635634 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U1F7W0
• Locus tag: HRI97_RS11820
• Protein ID: WP_021330949.1
• Coordinates: 2635049..2635342 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRI97_RS11805 (HRI97_11830)	2630572..2631489	-	918	WP_253725664.1	Ppx/GppA phosphatase family protein	-
HRI97_RS11810 (HRI97_11835)	2631501..2632091	-	591	WP_253725665.1	hypothetical protein	-
HRI97_RS11815 (HRI97_11840)	2632363..2634909	-	2547	WP_253725667.1	leucine-rich repeat domain-containing protein	-
HRI97_RS11820 (HRI97_11845)	2635049..2635342	-	294	WP_021330949.1	putative addiction module antidote protein	Antitoxin
HRI97_RS11825 (HRI97_11850)	2635326..2635634	-	309	WP_253725669.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HRI97_RS11830 (HRI97_11855)	2635799..2636224	-	426	WP_253725671.1	hypothetical protein	-
HRI97_RS11835 (HRI97_11860)	2636235..2638592	-	2358	WP_253725673.1	MMPL family transporter	-
HRI97_RS11840 (HRI97_11865)	2638564..2639193	-	630	WP_253725674.1	outer membrane lipoprotein carrier protein LolA	-
HRI97_RS11845 (HRI97_11870)	2639226..2639651	-	426	WP_253725676.1	thioesterase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (4-93)

Antitoxin

• Uncharacterized protein HI1420 (3-92)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11455.25 Da
• Isoelectric Point: 10.4668

>T159227 WP_253725669.1 NZ_CP054258:c2635634-2635326 [Treponema socranskii subsp. buccale]
VYKVLQTETYKKWFKKLRDERAKFAIGQRIARMTVGNFGDSKSVGGGVFELRIDVGKGYRVYFTNNGKRIVILLVGGDKS
TQDEDIKTAKKMAGGIDYGKID

Nucleotide

• Length: 309 bp

>T159227 NZ_CP069980:c4478600-4478322 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCATCGACTTGCTGTGATTGATGCGGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10699.22 Da
• Isoelectric Point: 4.8228

>AT159227 WP_021330949.1 NZ_CP054258:c2635342-2635049 [Treponema socranskii subsp. buccale]
MEKLTEFDMAEYLDTEELQKGYLDYNAKEGTPEDLLRAINAVARARGMTKTAKEAGITRDGLYKALAPEANPAFSTVFNI
LHAIGYTLTPTPIAKTM

Nucleotide

• Length: 294 bp

>AT159227 NZ_CP069980:c4478322-4478038 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAACGCCTGGAGTCTGGCAGAGGCTGAA
AAAACGGTGGATGTGTCGCGATTACGCCGTCTGGTTACGCAATAA

Structures

Antitoxin

• AlphaFold DB: U1F7W0