Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 685405..685993 Replicon chromosome
Accession NZ_CP054258
Organism Treponema socranskii subsp. buccale strain ATCC 35534

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HRI97_RS03055 Protein ID WP_253726451.1
Coordinates 685405..685698 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HRI97_RS03060 Protein ID WP_180487324.1
Coordinates 685700..685993 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRI97_RS03030 (HRI97_03035) 681439..682128 + 690 WP_253726441.1 tyrosine-protein phosphatase -
HRI97_RS03035 (HRI97_03040) 682249..683358 + 1110 WP_253726443.1 SAM-dependent chlorinase/fluorinase -
HRI97_RS03040 (HRI97_03045) 683546..683926 + 381 WP_253726445.1 hypothetical protein -
HRI97_RS03045 (HRI97_03050) 684329..684832 + 504 WP_253726447.1 hypothetical protein -
HRI97_RS03050 (HRI97_03055) 684883..685218 - 336 WP_253726449.1 hypothetical protein -
HRI97_RS03055 (HRI97_03060) 685405..685698 + 294 WP_253726451.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRI97_RS03060 (HRI97_03065) 685700..685993 + 294 WP_180487324.1 putative addiction module antidote protein Antitoxin
HRI97_RS03065 (HRI97_03070) 686121..686459 + 339 WP_253726453.1 helix-turn-helix transcriptional regulator -
HRI97_RS03070 (HRI97_03075) 686461..687135 + 675 WP_253726455.1 ImmA/IrrE family metallo-endopeptidase -
HRI97_RS03075 (HRI97_03080) 688642..688815 - 174 WP_253726457.1 hypothetical protein -
HRI97_RS03085 (HRI97_03090) 689865..690305 + 441 WP_253726459.1 D-aminoacyl-tRNA deacylase -
HRI97_RS03090 (HRI97_03095) 690405..690923 + 519 WP_253726461.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-89)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10904.62 Da        Isoelectric Point: 10.1552

>T159224 WP_253726451.1 NZ_CP054258:685405-685698 [Treponema socranskii subsp. buccale]
MNYEVRQTEEFSKWLKKLKDAVAKVAIARRIDRMTDGNFGDSKSVGGGVFELRVDVGKGYRVYFTNKNNKIVILLVGGDK
STQCEDIKIAKKMASEV

Download         Length: 294 bp

>T159224 NZ_CP069980:c4247640-4247533 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10719.20 Da        Isoelectric Point: 4.6386

>AT159224 WP_180487324.1 NZ_CP054258:685700-685993 [Treponema socranskii subsp. buccale]
MLKTTEFDIAEYLDTEELREGYLELVAKDGTQEELLRAINAVARARGMTETAKEAGITREGLYKALSPNGNPTFSTVWNV
LHAIGYTLTPTPIAKTM

Download         Length: 294 bp

>AT159224 NZ_CP069980:4247688-4247754 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References