Detailed information of TA system TA159223

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 2381196..2381761
• Replicon: chromosome
• Accession: NZ_CP054257
• Organism: Treponema parvum strain ATCC 700773

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: HRI96_RS10575
• Protein ID: WP_210117317.1
• Coordinates: 2381423..2381761 (+)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: HRI96_RS10570
• Protein ID: WP_210117316.1
• Coordinates: 2381196..2381429 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRI96_RS10540 (HRI96_10565)	2377173..2377961	-	789	WP_210117312.1	ABC transporter ATP-binding protein	-
HRI96_RS10545 (HRI96_10570)	2377958..2379016	-	1059	WP_210117313.1	iron ABC transporter permease	-
HRI96_RS10550 (HRI96_10575)	2379103..2379762	-	660	WP_210117314.1	MmcQ/YjbR family DNA-binding protein	-
HRI96_RS10555 (HRI96_10580)	2379729..2380076	-	348	WP_256729227.1	hypothetical protein	-
HRI96_RS10560 (HRI96_10585)	2380060..2380218	-	159	WP_256729228.1	hypothetical protein	-
HRI96_RS10565 (HRI96_10590)	2380428..2380967	-	540	WP_210117315.1	ClbS/DfsB family four-helix bundle protein	-
HRI96_RS10570 (HRI96_10595)	2381196..2381429	+	234	WP_210117316.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
HRI96_RS10575 (HRI96_10600)	2381423..2381761	+	339	WP_210117317.1	endoribonuclease MazF	Toxin
HRI96_RS10580 (HRI96_10605)	2382225..2382485	+	261	WP_210117318.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
HRI96_RS10585 (HRI96_10610)	2382482..2382742	+	261	WP_210117319.1	Txe/YoeB family addiction module toxin	-
HRI96_RS10590 (HRI96_10615)	2382948..2384069	+	1122	WP_210117320.1	ABC transporter ATP-binding protein	-
HRI96_RS10595 (HRI96_10620)	2384157..2385830	+	1674	WP_210117321.1	iron ABC transporter permease	-
HRI96_RS10600 (HRI96_10625)	2385871..2386026	-	156	WP_210117322.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (10-110)

Antitoxin

• SpoVT-AbrB domain (7-48)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12861.75 Da
• Isoelectric Point: 6.6947

>T159223 WP_210117317.1 NZ_CP054257:2381423-2381761 [Treponema parvum]
MVNSNYVPEKGDLVWLDFDPQTGHEQKGRRPAICISHKSYNQKIGLALFCPITSRIKGYPFEIVLNQHSINGCILSDQIK
NLNWKQRNCDFIEKAADEEIDSVVQNIKLMIE

Nucleotide

• Length: 339 bp

>T159223 NZ_CP069980:c4030831-4030337 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8586.90 Da
• Isoelectric Point: 7.2020

>AT159223 WP_210117316.1 NZ_CP054257:2381196-2381429 [Treponema parvum]
VQTIVHKWGNSLGFRIPSLWAKDNDIKNGSKVEVIIEKGKIVILPQKKSLDDMLALVNEENIHSEVSTGYAVGKEAW

Nucleotide

• Length: 234 bp

>AT159223 NZ_CP069980:c4031121-4030828 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAACCAGGCGCGAATCTTTAAATTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA