Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafQ-DinJ |
| Location | 2362842..2363392 | Replicon | chromosome |
| Accession | NZ_CP054257 | ||
| Organism | Treponema parvum strain ATCC 700773 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | HRI96_RS10470 | Protein ID | WP_210117298.1 |
| Coordinates | 2362842..2363123 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | HRI96_RS10475 | Protein ID | WP_210117299.1 |
| Coordinates | 2363120..2363392 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HRI96_RS10425 (HRI96_10450) | 2358232..2358366 | - | 135 | WP_256729224.1 | hypothetical protein | - |
| HRI96_RS10430 (HRI96_10455) | 2358433..2358831 | - | 399 | WP_210117291.1 | type II toxin-antitoxin system VapC family toxin | - |
| HRI96_RS10435 (HRI96_10460) | 2358815..2359093 | - | 279 | WP_210117292.1 | antitoxin | - |
| HRI96_RS11795 | 2359150..2359332 | - | 183 | Protein_2035 | competence protein TfoX | - |
| HRI96_RS11800 | 2359360..2359482 | + | 123 | WP_256729225.1 | hypothetical protein | - |
| HRI96_RS10440 (HRI96_10465) | 2359566..2359961 | - | 396 | WP_210117293.1 | type II toxin-antitoxin system VapC family toxin | - |
| HRI96_RS10445 (HRI96_10470) | 2359958..2360197 | - | 240 | WP_210117294.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HRI96_RS10450 (HRI96_10475) | 2360749..2361069 | + | 321 | WP_210117295.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HRI96_RS10455 (HRI96_10480) | 2361073..2361423 | + | 351 | WP_256729226.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HRI96_RS10460 (HRI96_10485) | 2361432..2361992 | + | 561 | WP_210117296.1 | hypothetical protein | - |
| HRI96_RS10465 (HRI96_10490) | 2362181..2362816 | - | 636 | WP_210117297.1 | alpha/beta hydrolase | - |
| HRI96_RS10470 (HRI96_10495) | 2362842..2363123 | - | 282 | WP_210117298.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| HRI96_RS10475 (HRI96_10500) | 2363120..2363392 | - | 273 | WP_210117299.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| HRI96_RS10480 (HRI96_10505) | 2363764..2364696 | - | 933 | WP_210117300.1 | NrtA/SsuA/CpmA family ABC transporter substrate-binding protein | - |
| HRI96_RS10485 (HRI96_10510) | 2364835..2365548 | - | 714 | WP_210117301.1 | ABC transporter ATP-binding protein | - |
| HRI96_RS10490 (HRI96_10515) | 2365535..2366314 | - | 780 | WP_210117302.1 | ABC transporter permease | - |
| HRI96_RS10495 (HRI96_10520) | 2366311..2366919 | - | 609 | WP_210117303.1 | hypothetical protein | - |
| HRI96_RS10500 (HRI96_10525) | 2367154..2367861 | - | 708 | WP_256729333.1 | SUMF1/EgtB/PvdO family nonheme iron enzyme | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 11020.83 Da Isoelectric Point: 10.1013
>T159222 WP_210117298.1 NZ_CP054257:c2363123-2362842 [Treponema parvum]
MKYEVKFTTQFKKDIKRAEKQNRNLNKLFGVIDLLVHGKPLEAKYRDHALSGKYKGTRECHIDPDWLLVYEHLNDVLVLM
LHRAGSHSELFRK
MKYEVKFTTQFKKDIKRAEKQNRNLNKLFGVIDLLVHGKPLEAKYRDHALSGKYKGTRECHIDPDWLLVYEHLNDVLVLM
LHRAGSHSELFRK
Download Length: 282 bp
>T159222 NZ_CP069980:c3743581-3743195 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10032.42 Da Isoelectric Point: 5.0941
>AT159222 WP_210117299.1 NZ_CP054257:c2363392-2363120 [Treponema parvum]
VTTTNLNIRTDKDIKDRAEALFSELGLTMTAAVNMFLRTALRENGIPFTLRLDIPNNLTESAITEGRKIAYDDSVKGYSN
ISDLRKALEV
VTTTNLNIRTDKDIKDRAEALFSELGLTMTAAVNMFLRTALRENGIPFTLRLDIPNNLTESAITEGRKIAYDDSVKGYSN
ISDLRKALEV
Download Length: 273 bp
>AT159222 NZ_CP069980:c3743205-3742876 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGAAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGACCGGAAGTTTT
TGCAAAGTAA
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGAAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGACCGGAAGTTTT
TGCAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|