Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-UPF0150
Location 1497826..1498385 Replicon chromosome
Accession NZ_CP054257
Organism Treponema parvum strain ATCC 700773

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HRI96_RS06720 Protein ID WP_210116634.1
Coordinates 1497826..1498011 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HRI96_RS06725 Protein ID WP_210116635.1
Coordinates 1498008..1498385 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRI96_RS06700 1493493..1494902 - 1410 WP_210116630.1 DNA polymerase III -
HRI96_RS06705 (HRI96_06730) 1494902..1495381 - 480 WP_210116631.1 CvpA family protein -
HRI96_RS06710 (HRI96_06735) 1495374..1496600 - 1227 WP_210116632.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase -
HRI96_RS06715 (HRI96_06740) 1496605..1497528 - 924 WP_210116633.1 ankyrin repeat domain-containing protein -
HRI96_RS06720 (HRI96_06745) 1497826..1498011 + 186 WP_210116634.1 type II toxin-antitoxin system HicA family toxin Toxin
HRI96_RS06725 (HRI96_06750) 1498008..1498385 + 378 WP_210116635.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HRI96_RS06730 (HRI96_06755) 1498553..1500478 - 1926 WP_210116636.1 FAD-dependent oxidoreductase -
HRI96_RS06735 (HRI96_06760) 1500628..1502415 - 1788 WP_210116637.1 flavocytochrome c -
HRI96_RS06740 (HRI96_06765) 1502592..1503374 - 783 WP_210116638.1 sulfite exporter TauE/SafE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-56)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-62)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6854.35 Da        Isoelectric Point: 10.6732

>T159220 WP_210116634.1 NZ_CP054257:1497826-1498011 [Treponema parvum]
MKDKDLLKLLLKDGWEMVAVKGGHHKITKNGKIEIIPVHGKDIKKGLLAAILKRTKLEVDK

Download         Length: 186 bp

>T159220 NZ_CP069980:c3078729-3078388 [Escherichia coli]
ATGTGGGACGTCGAGACAACGGAGACTTTCGACAACTGGTTTGATGCCCAGACTGTTGCGCTGAAAGAAGATTTACTTGC
TGCAATGCTGATTCTTGCTGAGTATGGCCCACAGTTGGGCAGACCCTTTGCGGATACGGTTAATGATTCACAGTTTTCAA
ATATGAAAGAATTACGCGTCCAACATCAGGGAAACCCGGTACGTGCTTTTTTTGCTTTCGATCCTGCGCGCCGTGGCATT
GTATTATGTGCGGGTGATAAAACGGGGTTAAATGAGAAAAAGTTTTATCGCGATATGATCAAGCTCGCTGATTCTGAATA
CCGTAAGCATCTGAAAAAGTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13843.83 Da        Isoelectric Point: 4.4178

>AT159220 WP_210116635.1 NZ_CP054257:1498008-1498385 [Treponema parvum]
MKVIYPAIFHGEDGGFWVEFPDLPGCTTQGDSQAETYINAVEAMELFLQDDYTVDTLPAASAANKIKPGKDSFVVFVCGE
YKENEKAVKKTLTIPFWLNVQAEKAGVNFSQTLQEALCKKLNVVM

Download         Length: 378 bp

>AT159220 NZ_CP069980:c3078378-3078079 [Escherichia coli]
ATGGCTACTCTAAAAGAACTGATGGCAAAGCAAAGCCCTGAAAGCCAGGTGCGTATTGCGGCAAAAGTTGAGGAAATGCG
CCAGACCATCGCCTTGCATCAGCTGAGAGAAGAACTCAATATTTCGCAAACGGAAATGGCGGCAGCGATGGGCATTAAGC
AACCGACTCTTGCAAAAATGGAGCAGGCAGATAACGATCCTCGGTTGTCTACGCTAAAACGCTATGTTGCGGCTTTAGGT
GGGGAATTGAGTATCGACGTTAAACTGCCGAATGGTAAGAGAATTGCATTTCAGATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References