159217

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 1117040..1118475 Replicon chromosome
Accession NZ_CP054256
Organism Mycoplasma mycoides strain T1/44 GP

Toxin (Protein)


Gene name abiEii Uniprot ID Q6MU66
Locus tag HR079_RS04860 Protein ID WP_011166377.1
Coordinates 1117636..1118475 (+) Length 280 a.a.

Antitoxin (Protein)


Gene name abiEi Uniprot ID A0A7U5HSJ1
Locus tag HR079_RS04855 Protein ID WP_015545367.1
Coordinates 1117040..1117636 (+) Length 199 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HR079_RS04840 (HR079_04840) 1112164..1112658 + 495 WP_011166381.1 membrane protein -
HR079_RS04845 (HR079_04845) 1112730..1115420 + 2691 WP_011166380.1 alanine--tRNA ligase -
HR079_RS04850 (HR079_04850) 1115526..1116830 + 1305 WP_011166379.1 BspA family leucine-rich repeat surface protein -
HR079_RS04855 (HR079_04855) 1117040..1117636 + 597 WP_015545367.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
HR079_RS04860 (HR079_04860) 1117636..1118475 + 840 WP_011166377.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
HR079_RS04870 (HR079_04870) 1119995..1121600 - 1606 Protein_983 IS1634 family transposase -
HR079_RS04875 (HR079_04875) 1121713..1121877 - 165 WP_015545676.1 hypothetical protein -
HR079_RS05670 1121946..1122140 - 195 WP_011166373.1 hypothetical protein -
HR079_RS05675 1122286..1122798 - 513 WP_015545636.1 hypothetical protein -
HR079_RS05680 1122871..1123296 - 426 WP_011166371.1 transglutaminase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-257)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-53)


Sequences

Toxin        


Download         Length: 280 a.a.        Molecular weight: 33073.99 Da        Isoelectric Point: 9.7009

>T159217 WP_011166377.1 NZ_CP054256:1117636-1118475 [Mycoplasma mycoides]
MNLQKLKSICKRLSSETKTNYNIILKHYFMISILEKIVKSKNKQNFVIKGGFLLSNMMSLNERTTQDIDCLIKGINFVKE
NILRTISDVLRYDFTDFIKYEIKEITEIKKRDKYNGFRVKILCKLEKLEEIVKIDLAIGDVVTPSEIKYNFRNIFSNSSF
EIQAYNLETILAEKIFIINNLNIQSTRIKDLYDIFLIYSFKEFEIDYNILKCACLNTFKKRNTVFNIDLVLSLLNEINQL
DIFELLNNYRQKYFYAQKIEFKILIKSVIKFLEKLKNI

Download         Length: 840 bp

>T159217 NZ_CP069980:c2630026-2629769 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 199 a.a.        Molecular weight: 23637.30 Da        Isoelectric Point: 9.3217

>AT159217 WP_015545367.1 NZ_CP054256:1117040-1117636 [Mycoplasma mycoides]
MNYKEQLIKEAKKRAGIITRKEIMNLKIPSIYITRMIRSNELEKVDIGIYALTSENWYYDPDYNFSIRHKTPIFSYTYAL
TFFDFTDVIPMFRDVTVYHGYNAHNLDPQTRVHYVSKDIYELGVVEVKTNCGNKIRAYDIERTICDFIKHRDKIEAELFA
KTMYKYSEYEKRDKKLHEYAKKMNIGKKVYEVFQVLV

Download         Length: 597 bp

>AT159217 NZ_CP069980:c2629757-2629212 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q6MU66

Antitoxin

Source ID Structure
AlphaFold DB A0A7U5HSJ1

References