Detailed information of TA system TA159213

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5134004..5135685
• Replicon: chromosome
• Accession: NZ_CP054254
• Organism: Klebsiella variicola strain FH-1

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: HL854_RS24845
• Protein ID: WP_040971114.1
• Coordinates: 5134004..5134921 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: HL854_RS24850
• Protein ID: WP_047667261.1
• Coordinates: 5134927..5135685 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HL854_RS24825	5129310..5130830	+	1521	WP_032756301.1	sugar ABC transporter ATP-binding protein	-
HL854_RS24830	5130827..5131825	+	999	WP_023296904.1	ribose ABC transporter permease	-
HL854_RS24835	5131856..5132797	+	942	WP_012543155.1	ABC transporter substrate-binding protein	-
HL854_RS24840	5132872..5133879	+	1008	WP_047667264.1	carbohydrate kinase family protein	-
HL854_RS24845	5134004..5134921	-	918	WP_040971114.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
HL854_RS24850	5134927..5135685	-	759	WP_047667261.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
HL854_RS24855	5135771..5136499	-	729	WP_008807258.1	response regulator transcription factor	-
HL854_RS24860	5136772..5138919	+	2148	WP_173818415.1	formate dehydrogenase subunit alpha	-
HL854_RS24865	5139537..5140223	+	687	WP_008807260.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34737.11 Da
• Isoelectric Point: 5.4707

>T159213 WP_040971114.1 NZ_CP054254:c5134921-5134004 [Klebsiella variicola]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRTIALPHIRDALARIAANLQQQ
AGMNAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDVDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T159213 NZ_CP069980:c1258213-1257899 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAATCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28684.04 Da
• Isoelectric Point: 10.0388

>AT159213 WP_047667261.1 NZ_CP054254:c5135685-5134927 [Klebsiella variicola]
MPSKLNWLLQNSAPGDVILQSWLSRHAISPSLAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLEQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVMLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT159213 NZ_CP069980:c1257902-1257486 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACGCCCAGGCGCTGGAACTGGTCGATCATCTGCTGCTCAACGATCCTGAAAATCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCTGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATTGGCAGTAAATCCATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA