Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 814478..815135 Replicon chromosome
Accession NZ_CP054254
Organism Klebsiella variicola strain FH-1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HL854_RS04075 Protein ID WP_002916310.1
Coordinates 814725..815135 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HL854_RS04070 Protein ID WP_002916312.1
Coordinates 814478..814744 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HL854_RS04045 809627..811060 - 1434 WP_032736405.1 6-phospho-beta-glucosidase BglA -
HL854_RS04050 811180..811908 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
HL854_RS04055 811959..812270 + 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
HL854_RS04060 812434..813093 + 660 WP_008806429.1 hemolysin III family protein -
HL854_RS04065 813249..814232 - 984 WP_173818012.1 tRNA-modifying protein YgfZ -
HL854_RS04070 814478..814744 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HL854_RS04075 814725..815135 + 411 WP_002916310.1 protein YgfX Toxin
HL854_RS04080 815142..815663 - 522 WP_008806427.1 flavodoxin FldB -
HL854_RS04085 815764..816660 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
HL854_RS04090 816683..817396 + 714 WP_032736403.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HL854_RS04095 817402..819135 + 1734 WP_012540594.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T159200 WP_002916310.1 NZ_CP054254:814725-815135 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T159200 NZ_CP069978:c3355040-3354867 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT159200 WP_002916312.1 NZ_CP054254:814478-814744 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT159200 NZ_CP069978:c3355364-3355068 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References