Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4611152..4611984 Replicon chromosome
Accession NZ_CP054236
Organism Escherichia coli strain EcPF5

Toxin (Protein)


Gene name yeeV Uniprot ID A0A426P9T8
Locus tag HR070_RS22080 Protein ID WP_001555674.1
Coordinates 4611610..4611984 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A085P7I7
Locus tag HR070_RS22075 Protein ID WP_001327592.1
Coordinates 4611152..4611520 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HR070_RS22035 4606743..4607423 + 681 WP_001282920.1 WYL domain-containing protein -
HR070_RS22040 4607571..4608248 + 678 WP_001519094.1 hypothetical protein -
HR070_RS22045 4608254..4608487 + 234 WP_001278282.1 DUF905 family protein -
HR070_RS22050 4608577..4609395 + 819 WP_021527435.1 DUF945 domain-containing protein -
HR070_RS22055 4609395..4609640 + 246 WP_001164966.1 hypothetical protein -
HR070_RS22060 4609734..4610207 + 474 WP_001313575.1 antirestriction protein -
HR070_RS22065 4610223..4610699 + 477 WP_001313574.1 RadC family protein -
HR070_RS22070 4610768..4610989 + 222 WP_000692323.1 DUF987 domain-containing protein -
HR070_RS22075 4611152..4611520 + 369 WP_001327592.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HR070_RS22080 4611610..4611984 + 375 WP_001555674.1 TA system toxin CbtA family protein Toxin
HR070_RS22085 4611981..4612472 + 492 WP_001555675.1 hypothetical protein -
HR070_RS22090 4612492..4612689 + 198 WP_000445282.1 DUF957 domain-containing protein -
HR070_RS22095 4612774..4613616 + 843 WP_001519083.1 DUF4942 domain-containing protein -
HR070_RS22100 4614365..4615903 + 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14205.16 Da        Isoelectric Point: 8.2918

>T159183 WP_001555674.1 NZ_CP054236:4611610-4611984 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPRF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAK

Download         Length: 375 bp

>T159183 NZ_CP069974:3650-4030 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTAGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13901.65 Da        Isoelectric Point: 6.3165

>AT159183 WP_001327592.1 NZ_CP054236:4611152-4611520 [Escherichia coli]
VSDTHHETNYPDDYNNRPWWGLPCTITPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT159183 NZ_CP069974:3429-3650 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A426P9T8

Antitoxin

Source ID Structure
AlphaFold DB A0A085P7I7

References