Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 843094..843929 Replicon chromosome
Accession NZ_CP054236
Organism Escherichia coli strain EcPF5

Toxin (Protein)


Gene name yeeV Uniprot ID S1PMM7
Locus tag HR070_RS04050 Protein ID WP_000854720.1
Coordinates 843094..843471 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1P8X0
Locus tag HR070_RS04055 Protein ID WP_001539669.1
Coordinates 843561..843929 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HR070_RS04015 838342..839325 - 984 WP_001296394.1 KpsF/GutQ family sugar-phosphate isomerase -
HR070_RS04020 840136..840291 - 156 WP_000729638.1 hypothetical protein -
HR070_RS04025 840783..841109 - 327 WP_000779482.1 type II toxin-antitoxin system RelE/ParE family toxin -
HR070_RS04030 841106..841369 - 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
HR070_RS04035 841441..842307 - 867 WP_001290179.1 DUF4942 domain-containing protein -
HR070_RS04040 842400..842597 - 198 WP_000839238.1 DUF957 domain-containing protein -
HR070_RS04045 842609..843097 - 489 WP_021517899.1 hypothetical protein -
HR070_RS04050 843094..843471 - 378 WP_000854720.1 TA system toxin CbtA family protein Toxin
HR070_RS04055 843561..843929 - 369 WP_001539669.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HR070_RS04060 844009..844230 - 222 WP_000691817.1 DUF987 domain-containing protein -
HR070_RS04065 844293..844769 - 477 WP_001537421.1 RadC family protein -
HR070_RS04070 844784..845269 - 486 WP_016230787.1 antirestriction protein -
HR070_RS04075 845360..846178 - 819 WP_001175162.1 DUF945 domain-containing protein -
HR070_RS04080 846268..846501 - 234 WP_001278283.1 DUF905 family protein -
HR070_RS04085 846507..847184 - 678 WP_001097301.1 hypothetical protein -
HR070_RS04090 847332..848012 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14089.02 Da        Isoelectric Point: 7.9087

>T159158 WP_000854720.1 NZ_CP054236:c843471-843094 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T159158 NZ_CP069973:c440973-440677 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13614.39 Da        Isoelectric Point: 5.9550

>AT159158 WP_001539669.1 NZ_CP054236:c843929-843561 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSN
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT159158 NZ_CP069973:c440675-440280 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FW05

Antitoxin

Source ID Structure
AlphaFold DB A0A829FYK7

References