Detailed information of TA system TA159143

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 3498232..3499046
• Replicon: chromosome
• Accession: NZ_CP054232
• Organism: Escherichia coli strain EcPF7

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: HR071_RS16825
• Protein ID: WP_001054376.1
• Coordinates: 3498789..3499046 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: A0A8E0IVE5
• Locus tag: HR071_RS16820
• Protein ID: WP_001350781.1
• Coordinates: 3498232..3498777 (-)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HR071_RS16795	3493923..3495236	-	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-
HR071_RS16800	3495248..3495526	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
HR071_RS16805	3495523..3496644	-	1122	WP_000010829.1	M42 family metallopeptidase	-
HR071_RS16810	3497043..3497261	-	219	Protein_3283	hypothetical protein	-
HR071_RS16815	3497430..3498176	-	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
HR071_RS16820	3498232..3498777	-	546	WP_001350781.1	N-acetyltransferase	Antitoxin
HR071_RS16825	3498789..3499046	-	258	WP_001054376.1	hypothetical protein	Toxin
HR071_RS16830	3499423..3499668	-	246	Protein_3287	GNAT family N-acetyltransferase	-
HR071_RS16835	3500038..3500958	+	921	Protein_3288	hypothetical protein	-
HR071_RS16840	3500956..3501653	-	698	Protein_3289	IS1 family transposase	-
HR071_RS16845	3502384..3503364	-	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T159143 WP_001054376.1 NZ_CP054232:c3499046-3498789 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T159143 NZ_CP069968:c3437772-3437488 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19974.91 Da
• Isoelectric Point: 6.3277

>AT159143 WP_001350781.1 NZ_CP054232:c3498777-3498232 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAFIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT159143 NZ_CP069968:c3438004-3437762 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: S1PA82